Zain I Khalpey

  • 1823 Citations
  • 19 h-Index
19962018
If you made any changes in Pure these will be visible here soon.

Research Output 1996 2018

2018
1 Citations
Antithrombins
Endocarditis
Cardiopulmonary Bypass
Mitral Valve
Inflammation
6 Citations

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H. , Babicheva, A. , McDermott, K. M. , Gu, Y. , Ayon, R. J. , Song, S. , Wang, Z. , Gupta, A. , Zhou, T. , Sun, X. , Dash, S. , Wang, Z. , Balistrieri, A. , Zheng, Q. , Cordery, A. G. , Desai, A. A. , Rischard, F. , Khalpey, Z. , Wang, J. , Black, S. M. & 3 others Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Feb 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

Pulmonary Hypertension
Endothelial Cells
Lung
Prolyl Hydroxylases
Smooth Muscle Myocytes

Parkinson's disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy

Teves, J. M. Y., Bhargava, V., Kirwan, K. R., Corenblum, M. J., Justiniano, R., Wondrak, G. T., Anandhan, A., Flores, A. J., Schipper, D. A., Khalpey, Z., Sligh, J. E., Curiel-Lewandrowski, C., Sherman, S. J. & Madhavan, L., Jan 12 2018, In : Frontiers in Neuroscience. 11, JAN, 737

Research output: Contribution to journalArticle

Autophagy
Oxidation-Reduction
Parkinson Disease
Homeostasis
Fibroblasts

Peripheral VA-ECMO with direct biventricular decompression for refractory cardiogenic shock

Rao, P., Mosier, J., Malo, J., Dotson, V., Mogan, C., Smith, R., Keller, R., Slepian, M. & Khalpey, Z., Feb 1 2018, (Accepted/In press) In : Perfusion (United Kingdom).

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Oxygenation
Cardiogenic Shock
Decompression
Refractory materials
1 Citations

Potential Impact of the Proposed Revised UNOS Thoracic Organ Allocation System

Rao, P., Smith, R. & Khalpey, Z., Jan 1 2018, (Accepted/In press) In : Seminars in Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Thorax
Equipment and Supplies
Waiting Lists
Heart Failure
Transplants
1 Citations

Regenerative concepts in cardiovascular research: Novel hybrid therapy for remodeling ischemic cardiomyopathy

Rao, P., Skaria, R. & Khalpey, Z., Jun 1 2018, In : Journal of Thoracic Disease. 10, p. S1819-S1824

Research output: Contribution to journalEditorial

Cardiomyopathies
Research
Therapeutics
Artificial Heart
Hemodynamics

Total artificial heart implantation in a young Marfan syndrome patient

Rao, P., Keenan, J. B., Rajab, T. K., Kim, S., Smith, R., Amabile, O. & Khalpey, Z., Feb 1 2018, (Accepted/In press) In : International Journal of Artificial Organs.

Research output: Contribution to journalArticle

Artificial heart
Artificial Heart
Marfan Syndrome
Dissection
Transplants
1 Citations

Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock

Rao, P., Smith, R. & Khalpey, Z., Oct 1 2018, In : JACC: Heart Failure. 6, 10, 1 p.

Research output: Contribution to journalLetter

Extracorporeal Membrane Oxygenation
Cardiogenic Shock
2017
2 Citations

A 24-year-old male with a painful and cold lower extremity

Robinson, E. A., Khalpey, Z. I. & Janardhanan, R., May 1 2017, In : Heart. 103, 10

Research output: Contribution to journalComment/debate

Heart Valve Prosthesis
Three-Dimensional Echocardiography
Aortic Valve Insufficiency
Doppler Echocardiography
Transesophageal Echocardiography
1 Citations

A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock

Kazui, T., Tran, P. L., Pilikian, T. R., Marsh, K. M., Runyan, R., Konhilas, J., Smith, R. & Khalpey, Z. I., Sep 7 2017, In : Journal of Cardiothoracic Surgery. 12, 1, 80

Research output: Contribution to journalArticle

Cardiogenic Shock
Stem Cells
Equipment and Supplies
Sternotomy
Cell- and Tissue-Based Therapy
1 Citations

Advantages and disadvantages of using intravenous tissue Plasminogen activator as salvage therapy for inoperable HeartWare thrombosis

Basken, R., Bazzell, C. M., Smith, R., Janardhanan, R. & Khalpey, Z., Jul 1 2017, In : Journal of Cardiac Surgery. 32, 7, p. 443-446 4 p.

Research output: Contribution to journalArticle

Salvage Therapy
Tissue Plasminogen Activator
Heart-Assist Devices
Thrombosis
Equipment and Supplies
3 Citations

Ambulatory central VA-ECMO with biventricular decompression for acute cardiogenic shock

Rao, P., Alouidor, B., Smith, R. & Khalpey, Z., Jan 1 2017, (Accepted/In press) In : Catheterization and Cardiovascular Interventions.

Research output: Contribution to journalArticle

Heart-Assist Devices
Cardiogenic Shock
Decompression
Membranes
Equipment and Supplies

Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis

Marsh, K. M., Ferng, A. S., Pilikian, T., Desai, A. A., Avery, R., Friedman, M., Oliva, I., Jokerst, C., Schipper, D. & Khalpey, Z., Jan 26 2017, In : Journal of Cardiothoracic Surgery. 12, 1, 6

Research output: Contribution to journalArticle

Pericardiectomy
Constrictive Pericarditis
Amnion
Anti-Inflammatory Agents
Thoracic Surgery
2 Citations

Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse

Danilo, C. A., Constantopoulos, E., McKee, L. A., Chen, H., Regan, J. A., Lipovka, Y., Lahtinen, S., Stenman, L. K., Nguyen, T. V. V., Doyle, K. P., Slepian, M. J., Khalpey, Z. I. & Konhilas, J. P., 2017, In : Beneficial microbes. 8, 2, p. 257-269 13 p.

Research output: Contribution to journalArticle

Myocardial Infarction
Probiotics
Anti-Inflammatory Agents
Bifidobacterium animalis
Reperfusion Injury

Bileaflet Foldoplasty in Barlow’s Disease

Khalpey, Z., Rawashdeh, B., Kazui, T. & Lick, S., May 1 2017, In : The Journal of heart valve disease. 26, 3, p. 355-357 3 p.

Research output: Contribution to journalArticle

Low Cardiac Output
Mitral Valve Insufficiency
Robotics
Mitral Valve
Therapeutics
3 Citations

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH

Song, S., Ayon, R. J., Yamamura, A., Yamamura, H., Dash, S., Babicheva, A., Tang, H., Sun, X., Cordery, A. G., Khalpey, Z., Black, S. M., Desai, A. A., Rischard, F., McDermott, K. M., Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L309-L325

Research output: Contribution to journalArticle

Capsaicin
Pulmonary Artery
Smooth Muscle Myocytes
vanilloid receptor subtype 1
Phosphorylation
2 Citations

Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Ferng, A., Connell, A., Nunez, M., Johnson, K., Braunhut, B., Lick, S., Desai, A., Kazui, T., Runyan, R. & Khalpey, Z., Sep 1 2017, In : Annals of Thoracic Surgery. 104, 3, p. e239-e241

Research output: Contribution to journalArticle

Heart Ventricles
Regeneration
Aorta
Heart-Assist Devices
Elastin
2 Citations

Changes in Tracheostomy- and Intubation-Related Tracheal Stenosis: Implications for Surgery

Kim, S. S., Khalpey, Z., Hsu, C. & Little, A. G., 2017, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

Tracheal Stenosis
Tracheostomy
Intubation
Pathologic Constriction
Kaplan-Meier Estimate
3 Citations

Chronic Myocardial Ischemia Leads to Loss of Maximal Oxygen Consumption and Complex I Dysfunction

Schipper, D. A., Palsma, R., Marsh, K. M., O'Hare, C., Dicken, D. S., Lick, S., Kazui, T., Johnson, K., Smolenski, R. T., Duncker, D. J. & Khalpey, Z., 2017, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

Oxygen Consumption
Myocardial Ischemia
Respiration
Atrial Appendage
Ischemia
2 Citations

Clinical outcomes meta-analysis: Measuring subendocardial perfusion and efficacy of transmyocardial laser revascularization with nuclear imaging

Iwanski, J., Knapp, S. M., Avery, R., Oliva, I., Wong, R. K., Runyan, R. B. & Khalpey, Z., May 19 2017, In : Journal of Cardiothoracic Surgery. 12, 1, 37

Research output: Contribution to journalReview article

Transmyocardial Laser Revascularization
Meta-Analysis
Perfusion
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography

Deletion of CD73 in mice leads to aortic valve dysfunction

Zukowska, P., Kutryb-Zajac, B., Jasztal, A., Toczek, M., Zabielska, M., Borkowski, T., Khalpey, Z., Smolenski, R. T. & Slominska, E. M., Jun 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 6, p. 1464-1472 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Aortic Valve
Adenosine
Alkaline Phosphatase
Diet

Improved metabolism and redox state with a novel preservation solution: Implications for donor lungs after cardiac death (DCD)

Schipper, D. A., Louis, A. V., Dicken, D. S., Johnson, K., Smolenski, R. T., Black, S. M., Runyan, R., Konhilas, J., Garcia, J. G. N. & Khalpey, Z., 2017, In : Pulmonary Circulation. 7, 2, p. 494-504 11 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Dextrans
Lung
Potassium
Transplants

Intracranial Hemorrhage in Patients with Durable Mechanical Circulatory Support Devices: Institutional Review and Proposed Treatment Algorithm

Ramey, W. L., Basken, R. L., Walter, C. M., Khalpey, Z., Lemole, G. M. & Dumont, T. M., Dec 1 2017, In : World Neurosurgery. 108, p. 826-835 10 p.

Research output: Contribution to journalArticle

Intracranial Hemorrhages
Equipment and Supplies
Heart-Assist Devices
Artificial Heart
Therapeutics
4 Citations

Intraoperative thermographic imaging to assess myocardial distribution of Del Nido cardioplegia

Rao, P., Keenan, J. B., Rajab, T. K., Ferng, A., Kim, S. & Khalpey, Z., Dec 1 2017, In : Journal of Cardiac Surgery. 32, 12, p. 812-815 4 p.

Research output: Contribution to journalArticle

Infrared Rays
Cardioplegic Solutions
Intraoperative Monitoring
Induced Heart Arrest
Computer Systems
1 Citations

Metabolic Impact of Rapamycin (Sirolimus) and B-Estradiol Using Mouse Embryonic Fibroblasts as a Model for Lymphangioleiomyomatosis

Marsh, K. M., Schipper, D., Ferng, A. S., Johnson, K., Fisher, J., Knapp, S., Dicken, D. & Khalpey, Z., Jun 2 2017, (Accepted/In press) In : Lung. p. 1-6 6 p.

Research output: Contribution to journalArticle

Lymphangioleiomyomatosis
Sirolimus
Estradiol
Fibroblasts
Oxygen Consumption

Minimally invasive insertion of off-pump central extracorporeal membrane oxygenation

Avery, R., Yu, S., Rao, P., Wong, R. & Khalpey, Z., 2017, (Accepted/In press) In : Journal of Cardiac Surgery.

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
5 Citations

Novel vs clinical organ preservation solutions: Improved cardiac mitochondrial protection

Ferng, A. S., Schipper, D., Connell, A. M., Marsh, K. M., Knapp, S. & Khalpey, Z., Jan 26 2017, In : Journal of Cardiothoracic Surgery. 12, 1, 7

Research output: Contribution to journalArticle

Organ Preservation Solutions
Oxygen Consumption
Reperfusion Injury
Cardiac Myoblasts
Transplants
1 Citations

Off-pump left ventricular assist device exchange via re-do left mini-thoracotomy with original outflow graft preservation

Iwanski, J., Tran, P. L., Jerman, C., Smith, R., Kazui, T. & Khalpey, Z., 2017, In : Perfusion (United Kingdom). 32, 3, p. 179-182 4 p.

Research output: Contribution to journalArticle

Left ventricular assist devices
Heart-Assist Devices
Thoracotomy
invasion
Grafts

Off Pump Robotic-Assisted LVAD (HeartWare, HVAD) Placement via Left Mini Thoracotomy

Pantino, D. W. & Khalpey, Z., Feb 1 2017, In : Operative Techniques in Thoracic and Cardiovascular Surgery. 22, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Sternotomy
Robotics
Thoracotomy
Thoracic Surgery
1 Citations

Real-Time Autofluorescence Imaging to Diagnose LVAD Driveline Infections

Keenan, J. B., Rajab, T. K., Armstrong, D. G. & Khalpey, Z., Jun 1 2017, In : Annals of Thoracic Surgery. 103, 6, p. e493-e495

Research output: Contribution to journalArticle

Optical Imaging
Asymptomatic Infections
Heart-Assist Devices
Wounds and Injuries
Infection
First-Pass Ventriculography
Heart-Assist Devices
Stroke Volume
Heart Failure
Radionuclide Angiography

Tissue Expander as a Routine Component of 5

Avery, R., Paidy, S. R., Keller, R., Lick, S., Smith, R. G. & Khalpey, Z., Jan 1 2017, In : Circulation: Heart Failure. 10, 1, e003765

Research output: Contribution to journalArticle

Tissue Expansion Devices
3 Citations

Translation of First North American 50 and 70 cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices

Ferng, A. S., Oliva, I., Jokerst, C., Avery, R., Connell, A. M., Tran, P. L., Smith, R. G. & Khalpey, Z., Aug 1 2017, In : Artificial Organs. 41, 8, p. 727-734 8 p.

Research output: Contribution to journalArticle

Artificial heart
Artificial Heart
Tomography
Equipment and Supplies
Thoracic Cavity
2016
1 Citations

Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles

Ferng, A. S., Marsh, K. M., Fleming, J. M., Conway, R. F., Schipper, D., Bajaj, N., Connell, A. M., Pilikian, T., Johnson, K., Runyan, R., Black, S. M., Szivek, J. A. & Khalpey, Z., Dec 1 2016, In : SpringerPlus. 5, 1, 2057

Research output: Contribution to journalArticle

Stromal Cells
Stem Cells
Energy Metabolism
Adipose Tissue
Respiration
1 Citations
Heart-Assist Devices
Aortic Valve Insufficiency
Aortic Valve
Transplants
Dilated Cardiomyopathy
6 Citations

A novel minimally invasive off-pump biventricular assist device insertion technique

Khalpey, Z., Smith, R., Echeverria, A., Le Tran, P. & Kazui, T., Jan 1 2016, In : Journal of Thoracic and Cardiovascular Surgery. 151, 1, p. e5-e7

Research output: Contribution to journalArticle

Interventional Radiography
Prosthesis Design
Prosthesis Implantation
Right Ventricular Function
Heart-Assist Devices
2 Citations

Aortic valve replacement for Libman-Sacks endocarditis

Keenan, J. B., Janardhanan, R., Larsen, B. T. & Khalpey, Z., 2016, In : BMJ Case Reports. 2016, 215914

Research output: Contribution to journalArticle

Endocarditis
Aortic Valve
Non-Infective Endocarditis
Embolectomy
Lupus Nephritis
1 Citations

A Physical Heart Failure Simulation System Utilizing the Total Artificial Heart and Modified Donovan Mock Circulation

Crosby, J. R., Decook, K. J., Tran, P. L., Betterton, E., Smith, R. G., Larson, D. F., Khalpey, Z. I., Burkhoff, D. & Slepian, M. J., 2016, (Accepted/In press) In : Artificial Organs.

Research output: Contribution to journalArticle

Artificial heart
Artificial Heart
Starlings
Hemodynamics
Heart Failure
1 Citations

Associations of prolonged QTc in sickle cell disease

Indik, J. H., Nair, V., Rafikov, R., Nyotowidjojo, I. S., Bisla, J., Kansal, M., Parikh, D. S., Robinson, M., Desai, A., Oberoi, M., Gupta, A., Abbasi, T., Khalpey, Z., Patel, A. R., Lang, R. M., Dudley, S. C., Choi, B. R., Garcia, J. G. N., Machado, R. F. & Desai, A. A., Oct 1 2016, In : PLoS One. 11, 10, e0164526

Research output: Contribution to journalArticle

sickle cell anemia
Sickle Cell Anemia
Hazards
electrocardiography
Electrocardiography

Difficult decisions in cardiothoracic surgery: Acute cardiogenic shock

Baker, Z. P., Keenan, J. B. & Khalpey, Z., Jan 1 2016, Surgical Decision Making: Beyond the Evidence Based Surgery. Springer International Publishing, p. 165-176 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiogenic Shock
Equipment and Supplies
Therapeutics
Perfusion
Morbidity
1 Citations

First North American 50cc Total Artificial Heart Experience: Conversion from a 70cc Total Artificial Heart

Khalpey, Z., Kazui, T., Ferng, A. S., Connell, A., Tran, P. L. L., Meyer, M., Rawashdeh, B., Smith, R. G., Sweitzer, N. K., Friedman, M., Lick, S., Slepian, M. J. J. & Copeland, J. G. G., Jan 20 2016, (Accepted/In press) In : ASAIO Journal.

Research output: Contribution to journalArticle

Artificial heart
Artificial Heart
Thorax
Transplants
Veins
4 Citations

Hemolysate-mediated platelet aggregation: An additional risk mechanism contributing to thrombosis of continuous flow ventricular assist devices

Tran, P. L., Pietropaolo, M. G., Valerio, L., Brengle, W., Wong, R. K., Kazui, T., Khalpey, Z. I., Redaelli, A., Sheriff, J., Bluestein, D. & Slepian, M. J., Jul 1 2016, In : Perfusion (United Kingdom). 31, 5, p. 401-408 8 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Platelets
Hemolysis
Platelet Aggregation
aggregation
6 Citations

Minimally invasive approach for percutaneous CentriMag right ventricular assist device support using a single PROTEKDuo Cannula

Kazui, T., Tran, P. L., Echeverria, A., Jerman, C. F., Iwanski, J., Kim, S. S., Smith, R. G. & Khalpey, Z. I., Aug 4 2016, In : Journal of Cardiothoracic Surgery. 11, 1, 123

Research output: Contribution to journalArticle

Heart-Assist Devices
Jugular Veins
Heart Atria
Pulmonary Artery
Rehabilitation
3 Citations

Minimally Invasive Implantation: The Procedure of Choice!

Schmitto, J. D., Deniz, E., Rojas, S. V., Maltais, S., Khalpey, Z., Hanke, J. S., Egger, C. & Haverich, A., Feb 1 2016, In : Operative Techniques in Thoracic and Cardiovascular Surgery. 21, 1, p. 65-78 14 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Minimally Invasive Surgical Procedures
Length of Stay
Survival Rate
Heart Failure
2 Citations

Nineteen-Millimeter Bioprosthetic Aortic Valves Are Safe and Effective for Elderly Patients With Aortic Stenosis

Khalpey, Z., Myers, P. O., McGurk, S., Schmitto, J. D., Nauta, F., Borstlap, W., Wiegerinck, E., Wu, J. & Cohn, L. H., Feb 1 2016, In : Annals of Thoracic Surgery. 101, 2, p. 650-657 8 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Aortic Valve
Prostheses and Implants
Bioprosthesis
Mortality

Novel method using rotational thromboelastography analysis for intraoperative management of device patient with heparin-induced thrombocytopenia

Iwanski, J., Kazui, T., Le Tran, P., Basken, R., Wong, R. K. & Khalpey, Z., Jan 11 2016, (Accepted/In press) In : Blood Coagulation and Fibrinolysis.

Research output: Contribution to journalArticle

Thrombelastography
Thrombocytopenia
Heparin
Equipment and Supplies
Thrombosis
2 Citations

Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies

Kutryb-Zajac, B., Yuen, A. H. Y., Khalpey, Z., Zukowska, P., Slominska, E. M., Taylor, P. M., Goldstein, S., Heacox, A. E., Lavitrano, M., Chester, A. H., Yacoub, M. H. & Smolenski, R. T., Apr 1 2016, In : Journal of Cardiovascular Translational Research. 9, 2, p. 119-126 8 p.

Research output: Contribution to journalArticle

Deamination
Adenosine Monophosphate
Aortic Valve
Heterografts
Adenosine
20 Citations

Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension

Tang, H., Yamamura, A., Yamamura, H., Song, S., Fraidenburg, D. R., Chen, J., Gu, Y., Pohl, N. M., Zhou, T., Jiménez-Pérez, L., Ayon, R. J., Desai, A. A., Goltzman, D., Rischard, F., Khalpey, Z., Black, S. M., Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Mar 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L846-L859

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Pulmonary Hypertension
Smooth Muscle Myocytes
Lung
Vasoconstriction

Remodeling an infarcted heart: novel hybrid treatment with transmyocardial revascularization and stem cell therapy

Iwanski, J., Wong, R. K., Larson, D. F., Ferng, A. S., Runyan, R. B., Goldstein, S. & Khalpey, Z., Dec 1 2016, In : SpringerPlus. 5, 1, 738

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Stem Cells
Coronary Artery Disease
Therapeutics
Cardiomyopathies