AGING, NEURODEGENERATIVE DISEASE, AND ANIMAL MODELS

  • Rance, Naomi E (PI)
  • Quaid, Kimberly (PI)
  • Olton, David (PI)
  • Ross, Christopher (PI)
  • Rutkowski, J. Lynn (PI)
  • Aturkkan, Jaylan (PI)
  • Cork, Linda (PI)
  • Martin, Lee (PI)
  • Folstein, Marshal (PI)
  • Muma, Nancy (PI)
  • Whitehouse, Peter (PI)
  • Gordon, Barry (PI)
  • Borchelt, David (PI)
  • Koliatsos, Vassilis (PI)
  • Lyketsos, Constantine (PI)
  • Wong, Philip (PI)
  • Brandt, Jason (PI)
  • Worley, Paul (PI)
  • Savonenko, Alena (PI)
  • O'Brien, Richard (PI)
  • Bandeen-Roche, Karen J. (PI)
  • Albert, Marilyn (PI)
  • Huganir, Richard (PI)
  • Bakker, Arnold (PI)
  • Becher, Mark (PI)
  • Walker, Lary (PI)
  • Thinakaran, Gopan (PI)
  • Sisodia, Sangram (PI)
  • Wilcox, Barbara (PI)
  • Steele, Cynthia (PI)
  • Kawas, Claudia (PI)
  • Price, Donald (PI)
  • Troncoso, Juan (PI)

Project: Research project

Project Details

Description

The Alzheimer's Disease Research Center (ADRC) at the Johns Hopkins
Medical Institutions (JHMI) has a commitment to investigations of aging
and age-associated diseases, particularly Alzheimer's disease (AD).
Because of the importance of age and genetic factors in the etiologies
of AD, the principal research focus of our ADRC is on the roles of age
and genes in these processes. Thus, with the support of Cores, the
research in Kawas' Project focuses on behavior-brain correlations in
intact aged individuals, elderly subjects with mild cognitive
impairments, and cases of AD at various stages of the disease. Of
particular importance are the studies of the Baltimore Longitudinal Study
of Aging (BLSA) cohort, a unique, extraordinarily well-characterized
group of subjects that have been followed for up to 30 years. Some of
these individuals will have serial imaging studies. Moreover, these
elderly subjects, who have detailed neuropsychological examinations, have
consented to autopsy so that brain tissues will be available for
research. Supported by the Neuropathology Core, Projects 18-20 take
advantage of transgenic technologies: to produce mice with mutations in
the amyloid precursor protein (APP) gene linked to familial AD or
hereditary cerebral hemorrhage with amyloid, Dutch type; to introduce
SOD1 genes with mutations linked to familial amyotrophic lateral
sclerosis into the mouse germline; and to overexpress or ablate the APP
gene. These animals will be studied using a variety of neurobiological
strategies that have proved to be very successful in other animal models
of age-associated disorders. These models will be of great value in
testing the etiological roles of these mutations in disease, in examining
the character/evolution of the pathology, in determining mechanisms of
cell dysfunction/death, and eventually, in testing novel therapies.
Additional studies relevant to aging and neurodegenerative diseases are
supported by our Pilots. Finally, our ADRC is committed to training
young physicians and scientists and in disseminating information
concerning age-associated diseases to families, caregivers, and other
health professionals.
StatusActive
Effective start/end date9/28/843/31/20

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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