Biosynthesis of deazapurine-containing metabolites

Research project

Description

DESCRIPTION (provided by applicant): All organisms produce a host of compounds that are generally not required in primary metabolic processes, but play important regulatory functions. These secondary metabolites have been exploited by every civilization to enhance life and cure human diseases. We know these as hormones, antibiotics, antitumor agents, and antivirals. Since these metabolites can harm cells if produced in excess, or if present when a need for them does not exist, their production is often strictly regulated. An understanding of how cells synthesize and regulate the production of secondary metabolites is essential if one is to be able to exploit them as human therapeutic agents. Deazapurines are secondary metabolites that are derived from purines and little is known about how they are synthesized in the cell. This proposal outlines studies on the biosynthesis of deazapurine-containing secondary metabolites by Streptomyces. Our goal is to bring to fore the tools of genomics, molecular biology and enzymology to form the framework of how these metabolites are synthesized, and to begin the process of exploring the chemistry that underlies the biosynthesis of these molecules.
StatusActive
Effective start/end date1/17/053/31/18

Funding

  • National Institutes of Health: $258,985.00
  • National Institutes of Health: $327,800.00
  • National Institutes of Health: $261,442.00
  • National Institutes of Health: $202,952.00
  • National Institutes of Health: $270,912.00
  • National Institutes of Health: $16,706.00
  • National Institutes of Health: $175,348.00
  • National Institutes of Health: $234,742.00
  • National Institutes of Health: $202,952.00
  • National Institutes of Health: $50,000.00
  • National Institutes of Health: $192,136.00
  • National Institutes of Health: $213,334.00
  • National Institutes of Health: $308,611.00
  • National Institutes of Health: $152,318.00
  • National Institutes of Health: $408,566.00
  • National Institutes of Health: $270,912.00

Fingerprint

Biosynthesis
Metabolites
secondary metabolites
biosynthesis
metabolites
cells
Molecules
Purines
Molecular biology
Antineoplastic Agents
Antiviral Agents
Hormones
Anti-Bacterial Agents
enzymology
antineoplastic agents
purines
human diseases
molecular biology
antibiotics
hormones

Keywords

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)