MOLECULAR MECHANISMS OF HIV1 MOTHER-INFANT TRANSMISSION

Project: Research project

Project Details

Description

DESCRIPTION: The goal of this application is to identify the molecular mechanisms of perinatal HIV-1 transmission with the aim of developing relevant strategies for prevention. The investigator posits that there are specific molecular and biological properties of HIV-1 that include the functional domains in the gp120 region of Env and the p17 region of Gag that are critical determinants of perinatal HIV-1 transmission. Hypothesis-driven studies are proposed to; determine the molecular properties of viruses transmitted from an infected mother to her infant, identify and characterize the viral determinants associated with perinatal HIV-1 transmission, and determine the biological properties of viruses that are or are not transmitted from a mother to her infant.
StatusFinished
Effective start/end date4/1/975/31/06

Funding

  • National Institutes of Health
  • National Institutes of Health: $265,125.00
  • National Institutes of Health: $106,050.00
  • National Institutes of Health: $106,050.00
  • National Institutes of Health
  • National Institutes of Health: $106,050.00

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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