NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE

Project: Research project

Description

The major goal in this laboratory will be to synthesize gram quantities
of biologically active peptides which are needed for biochemical,
pharmacological, biological and biophysical studies in this Program
Project. Facilities for synthesis, purification and analysis will be
available. The specific aims of The Core Facility are: 1. To prepare 1-2 g quantities of DPDPE and [p-ClPhe4]DPDPE in high
purity for a variety of biochemical, pharmacological, and biophysical
studies, as well as studies of bioavailability, biodegredation and
toxicity. 2. To prepare 1 g of [Cys5, Cys11]Dynorphin A1-11-NH2 for a wide
variety of biological studies as in 1. 3. To prepare 1 g of CTAP, a potent and highly eta opioid receptor
selective peptide, to assess its antagonist effect as an opioid and to
examine its biostability. 4. To prepare whether peptide ligands as needed in the various projects
of the Program Project. 5. To prepare quantities of the new compounds which cross the blood
brain barrier more effectively for extensive biological and
biodistribution studies.
StatusFinished
Effective start/end date9/30/893/31/16

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,147,018.00
  • National Institutes of Health: $1,124,728.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,211,770.00
  • National Institutes of Health: $99,990.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $25,425.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,045,343.00
  • National Institutes of Health
  • National Institutes of Health: $1,072,680.00
  • National Institutes of Health: $1,225,040.00
  • National Institutes of Health: $1,350,462.00
  • National Institutes of Health
  • National Institutes of Health: $1,195,221.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,245,002.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,186,822.00
  • National Institutes of Health: $1,338,501.00
  • National Institutes of Health: $128,350.00
  • National Institutes of Health
  • National Institutes of Health: $1,108,996.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,209,428.00
  • National Institutes of Health: $1,338,364.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,244,283.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $128,775.00
  • National Institutes of Health: $1,193,205.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,076,700.00
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

D-Penicillamine (2,5)-Enkephalin
Peptides
Ligands
Opioid Analgesics
Opioid Peptides
Substance-Related Disorders
delta Opioid Receptor
Opiate Alkaloids
Pain
Dynorphins
Purification
Pharmaceutical Preparations
Bradykinin Receptors
Therapeutics
mu Opioid Receptor
Chronic Pain
Peptidomimetics
Oligodeoxyribonucleotides
Opioid Receptors
Neuralgia

ASJC

  • Medicine(all)