ROLE OF HLA CLASS I MOLECULES IN THE CTL RESPONSE TO HIV

Project: Research project

Description

The HLA class I molecules are crucial in the recognition by cytolytic T
lymphocytes (CTL) of their targets. In virus infected cells, fragments of
viral peptides bind to class I molecules and this class I/peptide complex
is recognized by CTLs. T cells are important in the clearance of nearly all
virus infections. In the experiments proposed here we will examine the
binding of HIV encoded peptides to MHC class I molecules, and the
relationship between binding and CTL recognition. In addition, we will
undertake a detailed analysis of the interaction between HIV peptides and
class I products using a combination of peptide synthesis, and saturation
mutagenesis of the HLA genes. These experiments will provide important
information on the binding of HIV peptides of HLA and lay the groundwork
for the development of synthetic vaccines which can take into account the
variability of HLA.
StatusFinished
Effective start/end date7/1/906/30/01

Funding

  • National Institutes of Health: $176,684.00
  • National Institutes of Health: $269,137.00
  • National Institutes of Health
  • National Institutes of Health: $190,744.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $391,485.00

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HIV
Peptides
Human Immunodeficiency Virus Proteins
Molecules
Antigen Presentation
Cytotoxic T-Lymphocytes
Allergy and Immunology
Major Histocompatibility Complex
Synthetic Vaccines
Peptide Fragments
Transgenic Mice
Epitopes
Molecular Biology
Vaccines
Research Personnel
Technology
Viruses
T-Lymphocytes
T-cells
Infection

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)