VASCULAR TOXICITY OF SELECTED ENVIRONMENTAL POLLUTANTS

Project: Research project

Project Details

Description

My primary goal is to develop a vigorous research program to study
cellular and molecular mechanisms involved in the initiation and/or
progression vascular disorders upon exposure to
environmental/occupational toxins. Although during his first two years
at Texas A&M University Dr. Ramos was allowed to focus on research
activities, his teaching and administrative commitment will increase
significantly to 30-40% of his time in the coming years. A RCDA would
allow Dr. Ramos to continue to devote most of his efforts to research
and research-related activities. Under such conditions, Dr. Ramos
should be able to make significant contributions to the field of
toxicology, as well as vascular cell biology. Dr. Ramos is an Associate
Professor of Toxicology in the Department of Physiology and
Pharmacology, College of Veterinary Medicine at Texas A&M University.
He also holds joint appointments in the Department of Medical
Physiology, College of Medicine and the Texas Agricultural Experiment
Station. Approximately 750 square feet of well-equipped laboratory
space with an adjacent office are available to the principal
investigator. Additional laboratory and office space are available
within the Department of Medical Physiology. The Faculty of Toxicology
at Texas A&M University consists of 13 toxicologists within the College
of Veterinary Medicine, as well as 27 members from other Colleges within
the University System. This group encompasses scientists with a diverse
background which share a primary interest in Toxicology. The Department
of Medical Physiology consists of 8 faculty members sharing broad
interests in the area of vascular cell biology. The natural overlap of
these two groups with the research interests of the principal
investigator provide a rich scientific environment for the professional
development of the applicant. In this application, experiments are
proposed to test the hypothesis that allylamine and benzo(a)pyrene
induce erratic expression of oncogenes to cause the phenotypic
modulation of smooth muscle cells from a contractile to a more synthetic
state. Phenotypic expression is defined by morphologic,
ultrastructural, biochemical and functional criteria. The status of the
phosphoinositide signal transduction system will be evaluated to
determine if alterations in turnover are involved in the expression of
the synthetic phenotype. Studies will be conducted to determine if
erratic expression of cellular oncogenes in vivo and in vitro is
associated with chemical treatment. The data generated from these
studies can be used to better understand the role that exposure to
ubiquitous environmental contaminants plays in the development of
atherosclerosis and other pathological changes of the vascular wall.
StatusFinished
Effective start/end date7/1/928/31/97

Funding

  • National Institutes of Health: $69,120.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Environmental Science(all)
  • Medicine(all)

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