α-Azido acids for direct use in solid-phase peptide synthesis

Christian W. Torne, Peg Davis, Frank Porreca, Morten Meldal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Several new α-azido acids have been synthesized and their use in solid-phase peptide synthesis has been demonstrated. The azido group allows for high activation of the carboxyl group as an acid chloride without formation of byproductions and with no detectable racemization. An analog of Leu-enkephalin has been prepared and tested in the mouse vas deferens and guinea pig ileum bioassays: it displays moderate activity as the δ-opiod receptor.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalJournal of Peptide Science
Volume6
Issue number12
DOIs
StatePublished - 2000

Fingerprint

Solid-Phase Synthesis Techniques
Leucine Enkephalin
Peptides
Acids
Vas Deferens
Bioassay
Ileum
Biological Assay
Chlorides
Guinea Pigs
Chemical activation

Keywords

  • Azido acid
  • Enkephalin
  • N-protection
  • SPPS

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

α-Azido acids for direct use in solid-phase peptide synthesis. / Torne, Christian W.; Davis, Peg; Porreca, Frank; Meldal, Morten.

In: Journal of Peptide Science, Vol. 6, No. 12, 2000, p. 594-602.

Research output: Contribution to journalArticle

Torne, Christian W. ; Davis, Peg ; Porreca, Frank ; Meldal, Morten. / α-Azido acids for direct use in solid-phase peptide synthesis. In: Journal of Peptide Science. 2000 ; Vol. 6, No. 12. pp. 594-602.
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