α-Azido acids for direct use in solid-phase peptide synthesis

Christian W. Torne, Peg Davis, Frank Porreca, Morten Meldal

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Several new α-azido acids have been synthesized and their use in solid-phase peptide synthesis has been demonstrated. The azido group allows for high activation of the carboxyl group as an acid chloride without formation of byproductions and with no detectable racemization. An analog of Leu-enkephalin has been prepared and tested in the mouse vas deferens and guinea pig ileum bioassays: it displays moderate activity as the δ-opiod receptor.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalJournal of Peptide Science
Volume6
Issue number12
DOIs
StatePublished - 2000

Keywords

  • Azido acid
  • Enkephalin
  • N-protection
  • SPPS

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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