α-MSH analogues and adrenal zona glomerulosa function

G. P. Vinson, B. J. Whitehouse, A. Bateman, V. J. Hruby, T. K. Sawyer, P. S. Darman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Recent studies on the control of adrenal zona glomerulosa function and aldosterone secretion have focussed attention on the role of MSH- like peptides. In particular, at low concentrations, α-MSH has a specific stimulatory effect on rat adrenal glomerulosa cells. The synthesis of α-MSH analogues which have potent and prolonged effects on melanocyte systems offers new methods of examining the specificity of this response. Two peptides were tested in which potential for a β-turn configuration was stabilised. These were: [Nle4, D-Phe7]-α-MSH and the cyclic [cys4, Cys10]-α-MSH. In contrast to their effects on molanocyte systems, only [cys4, Cys10]-α-MSH stimulated glomerulosa cells, and it was equipotent with a α-MSH, while [Nle4, D-Phe7]-α-MSH and shorter fragments had no effect when added alone [Nle4, D-Phe7]-α-MSH, however, augmented the response of cells already maximally stimulated with α-MSH and in this respect its actions resembled those of γ-MSH and related peptides. The augmentation produced by [Nle4, D-Phe7]-α-MSH and γ3-MSH was not additive when the two peptides were added together with α-MSH. The results suggest that the specificity of the α-MSH receptors in rat adrenal glomerulosa cells and the peptide structure-function relationships in this system are different from those described for melanocytes.

Original languageEnglish (US)
Pages (from-to)603-610
Number of pages8
JournalLife Sciences
Volume35
Issue number6
DOIs
StatePublished - Aug 6 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'α-MSH analogues and adrenal zona glomerulosa function'. Together they form a unique fingerprint.

  • Cite this

    Vinson, G. P., Whitehouse, B. J., Bateman, A., Hruby, V. J., Sawyer, T. K., & Darman, P. S. (1984). α-MSH analogues and adrenal zona glomerulosa function. Life Sciences, 35(6), 603-610. https://doi.org/10.1016/0024-3205(84)90255-8