α1-Antitrypsin deficiency presenting with ascites and cirrhosis in the neonatal period

Fayez K. Ghishan, George F. Gray, Harry L. Greene

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We report a 2-wk-old baby with α1-antitrypsin deficiency of Pizz phenotype, who presented with massive ascites and hepatomegaly. Liver biopsy disclosed active established cirrhosis. Unlike all other reported newborns with Pizz type, the patient had no evidence of neonatal cholestatic jaundice. The presentation of Pizz with established liver cirrhosis at such an early age not only adds another cause of cryptogenic cirrhosis in the neonatal period, but also points to a liver insult in some patients with Pizz, which is already determined in utero.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalGastroenterology
Volume85
Issue number2
DOIs
StatePublished - Aug 1983
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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