β-Amino alcohols from amino acids: Chelation control via schiff bases.

Robin Polt, Matt A. Peterson

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Sequential addition of iBu2AIH and RLi or RMgX to Schiff base esters derived from amino acids provides a simple route to β-amino alcohols. The reaction procedes without racemization, and with high threo selectivity. Several representative sphingosines are synthesized.

Original languageEnglish (US)
Pages (from-to)4985-4986
Number of pages2
JournalTetrahedron Letters
Volume31
Issue number35
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'β-Amino alcohols from amino acids: Chelation control via schiff bases.'. Together they form a unique fingerprint.

  • Cite this