γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response

Xun Zeng, Yu Ling Wei, Jun Huang, Evan W. Newell, Hongxiang Yu, Brian A. Kidd, Michael S. Kuhns, Ray W. Waters, Mark M. Davis, Casey T. Weaver, Yueh Hsiu Chien

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human γδ T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific γδ T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow γδ T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.

Original languageEnglish (US)
Pages (from-to)524-534
Number of pages11
JournalImmunity
Volume37
Issue number3
DOIs
StatePublished - Sep 21 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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