δ-opioid receptor: The third extracellular loop determines naltrindole selectivity

Xiaoping Li, Eva V. Varga, Dagmar Stropova, Teresa Zalewska, Ewa Malatynska, Richard J. Knapp, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Human δ/μ-opioid receptor chimeras were constructed to determine the role of the second and third extracellular loops in alkaloid ligand selectivity. Exchanging the third extracellular loop of the δ-opioid receptor with that of the μ-opioid receptor dramatically decreased the affinity of naltrindole, but not that of morphine. The results suggest that different domains of the opioid receptor are involved in the binding of naltrindole and morphine.

Original languageEnglish (US)
Pages (from-to)R1-R2
JournalEuropean Journal of Pharmacology
Volume300
Issue number1-2
DOIs
StatePublished - Apr 4 1996

Keywords

  • Binding site
  • Human
  • Opiate
  • Opioid receptor

ASJC Scopus subject areas

  • Pharmacology

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    Li, X., Varga, E. V., Stropova, D., Zalewska, T., Malatynska, E., Knapp, R. J., Roeske, W. R., & Yamamura, H. I. (1996). δ-opioid receptor: The third extracellular loop determines naltrindole selectivity. European Journal of Pharmacology, 300(1-2), R1-R2. https://doi.org/10.1016/0014-2999(96)00098-2