Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

Thomas H. Burkey, Raymond M. Quock, Paul Consroe, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We measured the ability of the cannabinoid agonists Δ9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]l-1,4-benzoxazin-yl]-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding in mouse brain membranes. Δ9-Tetrahydrocannabinol stimulated [35S]GTPγS binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that Δ9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTPγS binding in the mouse brain.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume323
Issue number2-3
DOIs
StatePublished - Apr 4 1997
Externally publishedYes

Fingerprint

Cannabinoid Receptor Agonists
Dronabinol
Brain
Guanosine 5'-O-(3-Thiotriphosphate)
Mesylates
Membranes
Win 55212-2

Keywords

  • Δ-Tetrahydrocannabinol
  • Brain, mouse
  • G-protein

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. / Burkey, Thomas H.; Quock, Raymond M.; Consroe, Paul; Roeske, William R.; Yamamura, Henry I.

In: European Journal of Pharmacology, Vol. 323, No. 2-3, 04.04.1997.

Research output: Contribution to journalArticle

Burkey, Thomas H. ; Quock, Raymond M. ; Consroe, Paul ; Roeske, William R. ; Yamamura, Henry I. / Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. In: European Journal of Pharmacology. 1997 ; Vol. 323, No. 2-3.
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