Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

Thomas H. Burkey, Raymond M. Quock, Paul Consroe, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We measured the ability of the cannabinoid agonists Δ9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]l-1,4-benzoxazin-yl]-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding in mouse brain membranes. Δ9-Tetrahydrocannabinol stimulated [35S]GTPγS binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that Δ9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTPγS binding in the mouse brain.

Original languageEnglish (US)
Pages (from-to)R3-R4
JournalEuropean Journal of Pharmacology
Volume323
Issue number2-3
DOIs
StatePublished - Apr 4 1997
Externally publishedYes

Keywords

  • Brain, mouse
  • G-protein
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Δ<sup>9</sup>-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain'. Together they form a unique fingerprint.

  • Cite this