−1 Programmed Ribosomal Frameshifting as a Force-Dependent Process

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

−1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon–anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical properties of mRNA's slippery sequence as well as the mechanical stability of downstream mRNA structure motifs that give rise to frameshifting are discussed. Progress in technology, experimental assays, and data analysis methods hold promise for accurate physical modeling and quantitative understanding of −1 programmed ribosomal frameshifting.

Original languageEnglish (US)
Title of host publicationNanotechnology Tools for the Study of RNA
PublisherElsevier B.V.
Pages45-72
Number of pages28
DOIs
StatePublished - 2016

Publication series

NameProgress in Molecular Biology and Translational Science
Volume139
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • RNA
  • force
  • optical tweezers
  • single molecule
  • −1 programmed ribosomal frameshifting

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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