1-Year followup of cardiac status after Adriamycin therapy

M. J. Friedman, G. A. Ewy, S. E. Jones, D. Cruze, T. E. Moon

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To study the natural history of the alterations in cardiac function produced by Adriamycin therapy, serial M-mode echocardiograms, electrocardiograms, and systolic time intervals were obtained in 15 patients prior to Adriamycin therapy and at 3-month intervals during and 1 year after cessation of therapy. The echocardiographic E-point septal separation increased from a median 0 dose value of 0.40 cm to 0.70 cm (P<0.003) at the time of the maximum dose of Adriamycin. The electrocardiographic frontal plane voltage decreased 13% (P<0.008) and the pre-ejection period/left ventricular ejection time ratio increased from a median value of 0.37 to 0.40 (P<0.01) during this same period. During the first year after Adriamycin was discontinued, no significant change was noted in any of these values. Thus, as a group, the slight deterioration of ventricular function that occurred during Adriamycin therapy remained unimproved during the 1-year followup period.

Original languageEnglish (US)
Pages (from-to)1809-1816
Number of pages8
JournalCancer Treatment Reports
Volume63
Issue number11-12
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Friedman, M. J., Ewy, G. A., Jones, S. E., Cruze, D., & Moon, T. E. (1979). 1-Year followup of cardiac status after Adriamycin therapy. Cancer Treatment Reports, 63(11-12), 1809-1816.