14-3-3 proteins: Do they have a role in human cancer?

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalFuture Oncology
Volume1
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • 14-3-3
  • cancer
  • methylation
  • oncogene
  • p53
  • raf
  • tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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