[2,4-Diisoleucine]-oxytocin. An analog of oxytocin with natriuretic and diuretic activities

Victor J. Hruby, Vincent Du Vigneaud, W. Y. Chan

Research output: Research - peer-reviewArticle

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Abstract

[2,4-Diisoleucine]-oxytocin has been synthesized from the requisite protected nonapeptide intermediate which was prepared by the stepwise p-nitrophenyl ester method. In this analog of oxytocin, isoleucine residues replace the tyrosine and glutamine residues at the 2 and 4 positions of the hormone, and thus the isoleucine residue occurs successively at positions 2, 3, and 4. This compound possesses a very low level of avian vasodepressor, oxytocic, and pressor activities, and no antidiuretic activity. However, [2,4-diisoleucine]-oxytocin has a pronounced natriuretic activity and a mild diuretic effect.

LanguageEnglish (US)
Pages185-187
Number of pages3
JournalJournal of Medicinal Chemistry
Volume13
Issue number2
StatePublished - 1970
Externally publishedYes

Fingerprint

Oxytocin
Diuretics
Isoleucine
Oxytocics
Glutamine
Tyrosine
Esters
Hormones

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

[2,4-Diisoleucine]-oxytocin. An analog of oxytocin with natriuretic and diuretic activities. / Hruby, Victor J.; Du Vigneaud, Vincent; Chan, W. Y.

In: Journal of Medicinal Chemistry, Vol. 13, No. 2, 1970, p. 185-187.

Research output: Research - peer-reviewArticle

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