[2,4-Dileucine]oxytocin. A Polypeptide with Natriuretic and Diuretic Activities, and an Inhibitor of the Oxytocic Response of Oxytocin1a,b

Victor J. Hruby, W. Y. Chan

Research output: Contribution to journalArticle

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Abstract

[2,4-Dileucine]oxytocin, an analog of oxytocin in which the tyrosine in position 2 and the glutamine in position 4 have both been formally replaced by leucine, has been synthesized from the corresponding protected nonapeptide intermediate. The analog was found to possess negligible pressor activity and no antidiuretic or oxytocic activities. However, [2,4-dileucine]oxytocin has a natriuretic activity and a weak diuretic effect. Furthermore, it was shown to be an inhibitor to oxytocin in the oxytocic in vitro assay system.

Original languageEnglish (US)
Pages (from-to)1050-1051
Number of pages2
JournalJournal of Medicinal Chemistry
Volume14
Issue number11
DOIs
StatePublished - Nov 1 1971

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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