[2,4-Dileucine]oxytocin. A polypeptide with natriuretic and diuretic activities, and an inhibitor of the oxytocic response of oxytocin

Victor J. Hruby, W. Y. Chan

Research output: Research - peer-reviewArticle

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Abstract

[2,4-Dileucine]oxytocin, an analog of oxytocin in which the tyrosine in position 2 and the glutamine in position 4 have both been formally replaced by leucine, has been synthesized from the corresponding protected nonapeptide intermediate. The analog was found to possess negligible pressor activity and no antidiuretic or oxytocic activities. However, [2,4-dileucine]oxytocin has a natriuretic activity and a weak diuretic effect. Furthermore, it was shown to be an inhibitor to oxytocin in the oxytocic in vitro assay system.

LanguageEnglish (US)
Pages1050-1051
Number of pages2
JournalJournal of Medicinal Chemistry
Volume14
Issue number11
StatePublished - 1971

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Oxytocics
Oxytocin
Diuretics
Peptides
Glutamine
Leucine
Tyrosine
Assays
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "[2,4-Dileucine]oxytocin, an analog of oxytocin in which the tyrosine in position 2 and the glutamine in position 4 have both been formally replaced by leucine, has been synthesized from the corresponding protected nonapeptide intermediate. The analog was found to possess negligible pressor activity and no antidiuretic or oxytocic activities. However, [2,4-dileucine]oxytocin has a natriuretic activity and a weak diuretic effect. Furthermore, it was shown to be an inhibitor to oxytocin in the oxytocic in vitro assay system.",
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