3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl etherwater (2/0.72/1/1)

Isuru R. Kumarasinghe, Victor J Hruby, Gary S. Nichol

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1 Citation (Scopus)

Abstract

The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.

Original languageEnglish (US)
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume65
Issue number6
DOIs
StatePublished - 2009

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Methylene Chloride
Molecules
Hydrogen Bonding
Ether
Anti-Inflammatory Agents
Water
Hydrogen bonds
Pharmaceutical Preparations
Derivatives
3-(1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl)propanoic acid
propionic acid
pyrazole

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl etherwater (2/0.72/1/1)",
abstract = "The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.",
author = "Kumarasinghe, {Isuru R.} and Hruby, {Victor J} and Nichol, {Gary S.}",
year = "2009",
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T1 - 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl etherwater (2/0.72/1/1)

AU - Kumarasinghe, Isuru R.

AU - Hruby, Victor J

AU - Nichol, Gary S.

PY - 2009

Y1 - 2009

N2 - The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.

AB - The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.

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U2 - 10.1107/S010827010901676X

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JO - Acta Crystallographica Section C: Crystal Structure Communications

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IS - 6

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