3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl etherwater (2/0.72/1/1)

Isuru R. Kumarasinghe, Victor J. Hruby, Gary S. Nichol

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.

Original languageEnglish (US)
Pages (from-to)o296-o299
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume65
Issue number6
DOIs
StatePublished - Jul 24 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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