The structures of two related analogues 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl- 1H-pyrazol-3-yl]propanoic acids and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)- 1H-pyrazol-3-yl]propanoic acid-dichloromathane-diethyl ether-water has been reported. The compound was synthesized by a two step procedure using NaHMDS in place of LiHMDS. Nonsteroidal anti-inflammatory drugs are divided into three different categories. These structures makes use of hydrogen bonding and while compound forms a straight forward unsolvated Z equaling to structure compound crystallizes as an unusual mixed solvate with two crystallographically unique molecules of the pyrazole derivative present in the asymmetric unit. The molecules of dichloromethane are also found between the sheets and although there are no significant interactions between dichloromethane and adjacent molecules.
|Original language||English (US)|
|Journal||Acta Crystallographica Section C: Crystal Structure Communications|
|State||Published - Jul 24 2009|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)