3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Youhong Hu, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 22 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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