3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Youhong Hu, Emmanuelle Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 22 2001

Fingerprint

Phosphatidylinositol 3-Kinase
Carbonates
Cell growth
Inositol
Ether
Inhibitory Concentration 50
Phosphates
Cells
Lipids
Cell Line
Growth
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth. / Hu, Youhong; Meuillet, Emmanuelle; Berggren, Margareta; Powis, Garth; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 2, 22.01.2001, p. 173-176.

Research output: Contribution to journalArticle

@article{47cef3c9369c47909b2501f8703cd803,
title = "3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth",
abstract = "3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.",
author = "Youhong Hu and Emmanuelle Meuillet and Margareta Berggren and Garth Powis and Kozikowski, {Alan P.}",
year = "2001",
month = "1",
day = "22",
doi = "10.1016/S0960-894X(00)00640-5",
language = "English (US)",
volume = "11",
pages = "173--176",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - 3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

AU - Hu, Youhong

AU - Meuillet, Emmanuelle

AU - Berggren, Margareta

AU - Powis, Garth

AU - Kozikowski, Alan P.

PY - 2001/1/22

Y1 - 2001/1/22

N2 - 3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.

AB - 3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.

UR - http://www.scopus.com/inward/record.url?scp=0035931569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035931569&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)00640-5

DO - 10.1016/S0960-894X(00)00640-5

M3 - Article

VL - 11

SP - 173

EP - 176

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 2

ER -