3-(glutathion-S-yl)acetaminophen

A biliary metabolite of acetaminophen

J. A. Hinson, Terrence Monks, M. Hong, R. J. Highet, L. R. Pohl

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalDrug Metabolism and Disposition
Volume10
Issue number1
StatePublished - 1982
Externally publishedYes

Fingerprint

Acetaminophen
Metabolites
High performance liquid chromatography
Bile
Glutathione
Rats
High Pressure Liquid Chromatography
Nuclear magnetic resonance
3-(glutathion-S-yl)acetaminophen
Carbon-13 Magnetic Resonance Spectroscopy
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Hinson, J. A., Monks, T., Hong, M., Highet, R. J., & Pohl, L. R. (1982). 3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen. Drug Metabolism and Disposition, 10(1), 47-50.

3-(glutathion-S-yl)acetaminophen : A biliary metabolite of acetaminophen. / Hinson, J. A.; Monks, Terrence; Hong, M.; Highet, R. J.; Pohl, L. R.

In: Drug Metabolism and Disposition, Vol. 10, No. 1, 1982, p. 47-50.

Research output: Contribution to journalArticle

Hinson, JA, Monks, T, Hong, M, Highet, RJ & Pohl, LR 1982, '3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen', Drug Metabolism and Disposition, vol. 10, no. 1, pp. 47-50.
Hinson, J. A. ; Monks, Terrence ; Hong, M. ; Highet, R. J. ; Pohl, L. R. / 3-(glutathion-S-yl)acetaminophen : A biliary metabolite of acetaminophen. In: Drug Metabolism and Disposition. 1982 ; Vol. 10, No. 1. pp. 47-50.
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