3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson, T. J. Monks, M. Hong, R. J. Highet, L. R. Pohl

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalDrug Metabolism and Disposition
Volume10
Issue number1
StatePublished - Apr 16 1982

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Hinson, J. A., Monks, T. J., Hong, M., Highet, R. J., & Pohl, L. R. (1982). 3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen. Drug Metabolism and Disposition, 10(1), 47-50.