4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide

W. Y. Chan, Victor J Hruby, George Flouret, Vincent Du Vigneaud

Research output: Contribution to journalArticle

31 Scopus citations


During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

Original languageEnglish (US)
Pages (from-to)280-281
Number of pages2
Issue number3838
Publication statusPublished - 1968
Externally publishedYes


ASJC Scopus subject areas

  • General

Cite this

Chan, W. Y., Hruby, V. J., Flouret, G., & Du Vigneaud, V. (1968). 4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide. Science, 161(3838), 280-281.