4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide

W. Y. Chan, Victor J Hruby, George Flouret, Vincent Du Vigneaud

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

Original languageEnglish (US)
Pages (from-to)280-281
Number of pages2
JournalScience
Volume161
Issue number3838
StatePublished - 1968
Externally publishedYes

Fingerprint

Oxytocin
Diuretics
Leucine
Peptides
Water
Diuresis
Vasopressins
Urine
Sodium Chloride
Electrolytes
Potassium

ASJC Scopus subject areas

  • General

Cite this

Chan, W. Y., Hruby, V. J., Flouret, G., & Du Vigneaud, V. (1968). 4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide. Science, 161(3838), 280-281.

4-leucine-oxytocin : Natriuretic, diuretic, and antivasopressin polypeptide. / Chan, W. Y.; Hruby, Victor J; Flouret, George; Du Vigneaud, Vincent.

In: Science, Vol. 161, No. 3838, 1968, p. 280-281.

Research output: Contribution to journalArticle

Chan, WY, Hruby, VJ, Flouret, G & Du Vigneaud, V 1968, '4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide', Science, vol. 161, no. 3838, pp. 280-281.
Chan WY, Hruby VJ, Flouret G, Du Vigneaud V. 4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide. Science. 1968;161(3838):280-281.
Chan, W. Y. ; Hruby, Victor J ; Flouret, George ; Du Vigneaud, Vincent. / 4-leucine-oxytocin : Natriuretic, diuretic, and antivasopressin polypeptide. In: Science. 1968 ; Vol. 161, No. 3838. pp. 280-281.
@article{eb017d2fb87e449ca2f96a0d5722d93f,
title = "4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide",
abstract = "During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.",
author = "Chan, {W. Y.} and Hruby, {Victor J} and George Flouret and {Du Vigneaud}, Vincent",
year = "1968",
language = "English (US)",
volume = "161",
pages = "280--281",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "3838",

}

TY - JOUR

T1 - 4-leucine-oxytocin

T2 - Natriuretic, diuretic, and antivasopressin polypeptide

AU - Chan, W. Y.

AU - Hruby, Victor J

AU - Flouret, George

AU - Du Vigneaud, Vincent

PY - 1968

Y1 - 1968

N2 - During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

AB - During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

UR - http://www.scopus.com/inward/record.url?scp=0014422972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014422972&partnerID=8YFLogxK

M3 - Article

C2 - 5657333

AN - SCOPUS:0014422972

VL - 161

SP - 280

EP - 281

JO - Science

JF - Science

SN - 0036-8075

IS - 3838

ER -