4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT

Siyu Ma, Rui Wang, Richard L. Goodwin, Roger R. Markwald, Thomas K. Borg, Raymond B Runyan, Bruce Z. Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Congenital Heart Disease (CHD) is the most common congenital malformation in newborns in the US. Although knowledge of CHD is limited, altered hemodynamic conditions are suspected as the factor that stimulates cardiovascular cell response, resulting in the heart morphology remodeling that ultimately causes CHDs. Therefore, one of recent efforts in CHD study is to develop high-speed imaging tools to correlate the rapidly changing hemodynamic condition and the morphological adaptations of an embryonic heart in vivo. We have developed a high-speed streak mode OCT that works at the center wavelength of 830 nm and is capable of providing images (292×220 μm2) of the outflow tract of an embryonic chick heart at the rate of 1000 Hz. The modality can provide a voxel resolution in the range of 10 μm3, and the spectral resolution allows a depth range of 1.63 mm. In the study reported here, each of the 4D images of an outflow tract was recorded for 2 seconds. The recording was conducted every 2 hours (HH17 to HH18), 3 hours (HH14 to HH17), and 4 hours (HH18 to HH19). Because of the fast scan speed, there is no need for postacquisition processing such as use of gating techniques to provide a fine 3D structure. In addition, more details of the outflow tract are preserved in the recorded images. The 4D images can be used in the future to determine the role of blood flow in CHD development.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8580
DOIs
StatePublished - 2013
EventDynamics and Fluctuations in Biomedical Photonics VIII Conference - San Francisco, CA, United States
Duration: Feb 2 2013Feb 4 2013

Other

OtherDynamics and Fluctuations in Biomedical Photonics VIII Conference
CountryUnited States
CitySan Francisco, CA
Period2/2/132/4/13

Fingerprint

heart diseases
Heart Diseases
Display devices
high speed
hemodynamics
Hemodynamics
blood flow
spectral resolution
Heart Rate
fine structure
recording
Spectral resolution
causes
cells
wavelengths
Blood
Imaging techniques
Wavelength
Processing

Keywords

  • CHDs
  • Embryonic chick heart
  • High speed imaging
  • Outflow tract
  • Streak mode OCT

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ma, S., Wang, R., Goodwin, R. L., Markwald, R. R., Borg, T. K., Runyan, R. B., & Gao, B. Z. (2013). 4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8580). [85801G] https://doi.org/10.1117/12.2004588

4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT. / Ma, Siyu; Wang, Rui; Goodwin, Richard L.; Markwald, Roger R.; Borg, Thomas K.; Runyan, Raymond B; Gao, Bruce Z.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8580 2013. 85801G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ma, S, Wang, R, Goodwin, RL, Markwald, RR, Borg, TK, Runyan, RB & Gao, BZ 2013, 4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8580, 85801G, Dynamics and Fluctuations in Biomedical Photonics VIII Conference, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2004588
Ma S, Wang R, Goodwin RL, Markwald RR, Borg TK, Runyan RB et al. 4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8580. 2013. 85801G https://doi.org/10.1117/12.2004588
Ma, Siyu ; Wang, Rui ; Goodwin, Richard L. ; Markwald, Roger R. ; Borg, Thomas K. ; Runyan, Raymond B ; Gao, Bruce Z. / 4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8580 2013.
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