5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Kevin Schofield; Christopher Foley; Christopher Hulme

doi:10.1021/acs.orglett.0c03785

5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Kevin Schofield, Christopher Foley, Christopher Hulme

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

Original language	English (US)
Pages (from-to)	107-112
Number of pages	6
Journal	Organic Letters
Volume	23
Issue number	1
DOIs	https://doi.org/10.1021/acs.orglett.0c03785
State	Published - Jan 1 2021

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.0c03785

Cite this

@article{b94c0122a39e4d17b196271650f5f33b,

title = "5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones",

abstract = "A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.",

author = "Kevin Schofield and Christopher Foley and Christopher Hulme",

year = "2021",

month = jan,

day = "1",

doi = "10.1021/acs.orglett.0c03785",

language = "English (US)",

volume = "23",

pages = "107--112",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - 5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

AU - Schofield, Kevin

AU - Foley, Christopher

AU - Hulme, Christopher

PY - 2021/1/1

Y1 - 2021/1/1

N2 - A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

AB - A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

UR - http://www.scopus.com/inward/record.url?scp=85098770313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85098770313&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.0c03785

DO - 10.1021/acs.orglett.0c03785

M3 - Article

C2 - 33306404

AN - SCOPUS:85098770313

VL - 23

SP - 107

EP - 112

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 1

ER -

5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this