5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Kevin Schofield; Christopher Foley; Christopher Hulme

doi:10.1021/acs.orglett.0c03785

5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Kevin Schofield, Christopher Foley, Christopher Hulme

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

Abstract

A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

Original language	English (US)
Pages (from-to)	107-112
Number of pages	6
Journal	Organic Letters
Volume	23
Issue number	1
DOIs	https://doi.org/10.1021/acs.orglett.0c03785
State	Published - Jan 1 2021

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "5- Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones",

abstract = "A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.",

author = "Kevin Schofield and Christopher Foley and Christopher Hulme",

note = "Funding Information: We thank the X-ray Crystallography and Mass Spectrometry Facilities at the University of Arizona. The Biological Chemistry Program is thanked for a fellowship to C.F. (No. T32 GM008804).",

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AU - Foley, Christopher

AU - Hulme, Christopher

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N2 - A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones with three diversity elements. This adaptation of our previously described multicomponent reaction-oxidation methodology further showcases manipulation of the diversity elements in multicomponent reaction products via oxidative radical cyclizations, which generates highly decorated privileged heterocycles.

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