6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist

David F. Woodward, David J. Pepperl, Thomas H. Burkey, John W Regan

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP2 receptor (Regan et al., Mol Pharmacol 46: 213-220, 1994), we discovered that the putative EP1 receptor antagonist 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809) also has affinity for the human EP2 receptor. Moreover, AH 6809 behaved as an EP2 receptor antagonist and inhibited prostaglandin E2 (PGE2)-stimulated increases in cyclic AMP. These findings have significant implications for studies that employ AH 6809 to determine the pharmacological basis of PGE2-induced responses in human cells and tissues.

Original languageEnglish (US)
Pages (from-to)1731-1733
Number of pages3
JournalBiochemical Pharmacology
Volume50
Issue number10
DOIs
StatePublished - Nov 9 1995

Fingerprint

Dinoprostone
Cyclic AMP
Cells
Pharmacology
Tissue
Ligands
6-isopropoxy-9-oxoxanthene-2-carboxylic acid

Keywords

  • adenylyl cyclase
  • AH 6809
  • cAMP
  • G-protein coupled receptor
  • prostaglandins

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Cite this

6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. / Woodward, David F.; Pepperl, David J.; Burkey, Thomas H.; Regan, John W.

In: Biochemical Pharmacology, Vol. 50, No. 10, 09.11.1995, p. 1731-1733.

Research output: Contribution to journalArticle

Woodward, David F. ; Pepperl, David J. ; Burkey, Thomas H. ; Regan, John W. / 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. In: Biochemical Pharmacology. 1995 ; Vol. 50, No. 10. pp. 1731-1733.
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