6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist

David F. Woodward, David J. Pepperl, Thomas H. Burkey, John W. Regan

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP2 receptor (Regan et al., Mol Pharmacol 46: 213-220, 1994), we discovered that the putative EP1 receptor antagonist 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809) also has affinity for the human EP2 receptor. Moreover, AH 6809 behaved as an EP2 receptor antagonist and inhibited prostaglandin E2 (PGE2)-stimulated increases in cyclic AMP. These findings have significant implications for studies that employ AH 6809 to determine the pharmacological basis of PGE2-induced responses in human cells and tissues.

Original languageEnglish (US)
Pages (from-to)1731-1733
Number of pages3
JournalBiochemical Pharmacology
Volume50
Issue number10
DOIs
StatePublished - Nov 9 1995

Keywords

  • AH 6809
  • G-protein coupled receptor
  • adenylyl cyclase
  • cAMP
  • prostaglandins

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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