7 Tesla MR imaging of the human eye in vivo

Kathryn Richdale, Peter Wassenaar, Katharine Teal Bluestein, Amir Abduljalil, John B Christoforidis, Titus Lanz, Michael V. Knopp, Petra Schmalbrock

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose: To develop a protocol which optimizes contrast, resolution and scan time for three-dimensional (3D) imaging of the human eye in vivo using a 7 Tesla (T) scanner and custom radio frequency (RF) coil. Materials and Methods: Initial testing was conducted to reduce motion and susceptibility artifacts. Three-dimensional FFE and IR-TFE images were obtained with variable flip angles and TI times. T1 measurements were made and numerical simulations were performed to determine the ideal contrast of certain ocular structures. Studies were performed to optimize resolution and signalto-noise ratio (SNR) with scan times from 20 s to 5 min. Results: Motion and susceptibility artifacts were reduced through careful subject preparation. T1 values of the ocular structures are in line with previous work at 1.5T. A voxel size of 0.15 x 0.25 x 1.0 mm3 was obtained with a scan time of approximately 35 s for both 3D FFE and IR-TFE sequences. Multiple images were registered in 3D to produce final SNRs over 40. Conclusion: Optimization of pulse sequences and avoidance of susceptibility and motion artifacts led to high quality images with spatial resolution and SNR exceeding prior work. Ocular imaging at 7T with a dedicated coil improves the ability to make measurements of the fine structures of the eye.

Original languageEnglish (US)
Pages (from-to)924-932
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number5
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Artifacts
Polytetrafluoroethylene
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Three-Dimensional Imaging
Radio

Keywords

  • 7T MRI
  • Eye
  • Presbyopia
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Richdale, K., Wassenaar, P., Bluestein, K. T., Abduljalil, A., Christoforidis, J. B., Lanz, T., ... Schmalbrock, P. (2009). 7 Tesla MR imaging of the human eye in vivo. Journal of Magnetic Resonance Imaging, 30(5), 924-932. https://doi.org/10.1002/jmri.21959

7 Tesla MR imaging of the human eye in vivo. / Richdale, Kathryn; Wassenaar, Peter; Bluestein, Katharine Teal; Abduljalil, Amir; Christoforidis, John B; Lanz, Titus; Knopp, Michael V.; Schmalbrock, Petra.

In: Journal of Magnetic Resonance Imaging, Vol. 30, No. 5, 11.2009, p. 924-932.

Research output: Contribution to journalArticle

Richdale, K, Wassenaar, P, Bluestein, KT, Abduljalil, A, Christoforidis, JB, Lanz, T, Knopp, MV & Schmalbrock, P 2009, '7 Tesla MR imaging of the human eye in vivo', Journal of Magnetic Resonance Imaging, vol. 30, no. 5, pp. 924-932. https://doi.org/10.1002/jmri.21959
Richdale K, Wassenaar P, Bluestein KT, Abduljalil A, Christoforidis JB, Lanz T et al. 7 Tesla MR imaging of the human eye in vivo. Journal of Magnetic Resonance Imaging. 2009 Nov;30(5):924-932. https://doi.org/10.1002/jmri.21959
Richdale, Kathryn ; Wassenaar, Peter ; Bluestein, Katharine Teal ; Abduljalil, Amir ; Christoforidis, John B ; Lanz, Titus ; Knopp, Michael V. ; Schmalbrock, Petra. / 7 Tesla MR imaging of the human eye in vivo. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 30, No. 5. pp. 924-932.
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