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  • Joe GN Garcia
2016

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo De La Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. GN. & Zhang, D., Jan 5 2016, In : Scientific Reports. 6, 18760.

Research output: Contribution to journalArticle

27 Scopus citations
2015

American medical education at a crossroads

Feldman, A. M., Runge, M. S., Garcia, J. G. N. & Rubenstein, A. H., Apr 29 2015, In : Science translational medicine. 7, 285, 285fs17.

Research output: Contribution to journalArticle

7 Scopus citations
2017

The ARP 2/3 complex mediates endothelial barrier function and recovery

Belvitch, P., Brown, M. E., Brinley, B. N., Letsiou, E., Rizzo, A. N., Garcia, J. G. N. & Dudek, S. M., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Lung vascular dysfunction and repair in acute lung injury: Role of the endothelial cytoskeleton

Lang, G. D., Chiang, E. T. & Garcia, J. GN., Apr 19 2016, Acute Respiratory Distress Syndrome, Second Edition. CRC Press, p. 262-286 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2014
19 Scopus citations
2013

Transcriptional Events during the Recovery from MRSA Lung Infection: A Mouse Pneumonia Model

Chen, J., Feng, G., Guo, Q., Wardenburg, J. B., Lin, S., Inoshima, I., Deaton, R., Yuan, J. X. J., Garcia, J. G. N., Machado, R. F., Otto, M. & Wunderink, R. G., Aug 1 2013, In : PloS one. 8, 8, e70176.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury

Wang, T., Mathew, B., Wu, X., Shimizu, Y., Rizzo, A. N., Dudek, S. M., Weichselbaum, R. R., Jacobson, J. R., Hecker, L. & Garcia, J. G. N., Jun 2016, In : Pulmonary Circulation. 6, 2, p. 234-239 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
8 Scopus citations
2014

Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics

Belvitch, P., Adyshev, D., Elangovan, V. R., Brown, M. E., Naureckas, C., Rizzo, A. N., Siegler, J. H., Garcia, J. G. N. & Dudek, S. M., Jan 1 2014, In : Microvascular Research. 95, 1, p. 94-102 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Nano-Biomechanical Study of Spatio-Temporal Cytoskeleton Rearrangements that Determine Subcellular Mechanical Properties and Endothelial Permeability

Wang, X., Bleher, R., Brown, M. E., Garcia, J. GN., Dudek, S. M., Shekhawat, G. S. & Dravid, V. P., Jun 18 2015, In : Scientific Reports. 5, 11097.

Research output: Contribution to journalArticle

22 Scopus citations
2017

Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium

Wang, X., Bleher, R., Wang, L., Garcia, J. G. N., Dudek, S. M., Shekhawat, G. S. & Dravid, V. P., Dec 1 2017, In : Scientific reports. 7, 1, 14152.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Rapid porcine lung decellularization using a novel organ regenerative control acquisition bioreactor

Khalpey, Z., Qu, N., Hemphill, C., Louis, A. V., Ferng, A. S., Son, T. G., Stavoe, K., Penick, K., Tran, P. L., Konhilas, J., Lagrand, D. S. & Garcia, J. G. N., Jan 13 2015, In : ASAIO Journal. 61, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl

Wang, L., Chiang, E. T., Simmons, J. T., Garcia, J. G. N. & Dudek, S. M., Jul 1 2011, In : European Respiratory Journal. 38, 1, p. 78-88 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

Plasma metabolomic profile in fibrosing pulmonary sarcoidosis

Mirsaeidi, M., Banoei, M. M., Nienow, C. K., Abassi, T., Hakim, A., Schraufnagel, D., Winston, B. W., Sweiss, N., Baughman, R., Garcia, J. GN. & Machado, R., 2016, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 33, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform

Han, Y. J., Ma, S. F., Wade, M. S., Flores, C. & Garcia, J. G. N., Mar 1 2012, In : Journal of Molecular Medicine. 90, 3, p. 299-308 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-seq samples: Towards precision medicine

Gardeux, V., Achour, I., Li, J., Maienschein-Cline, M., Li, H., Pesce, L., Parinandi, G., Bahroos, N., Winn, R., Foster, I., Garcia, J. G. N. & Lussier, Y. A., Jan 1 2014, In : Journal of the American Medical Informatics Association. 21, 6, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Acosta-Herrera, M., Pino-Yanes, M., Ma, S. F., Barreto-Luis, A., Corrales, A., Cumplido, J., Pérez-Rodríguez, E., Campo, P., Eng, C., García-Robaina, J. C., Quintela, I., Villar, J., Blanca, M., Carracedo, Á., Carrillo, T., Garcia, J. GN., Torgerson, D. G., Burchard, E. G. & Flores, C., Oct 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 4, p. 1116-1118e9

Research output: Contribution to journalArticle

5 Scopus citations
2019

Gene editing of α6 integrin inhibits muscle invasive networks and increases cell-cell biophysical properties in prostate cancer

Rubenstein, C. S., Gard, J. M. C., Wang, M., McGrath, J. E., Ingabire, N., Hinton, J. P., Marr, K. D., Simpson, S. J., Nagle, R. B., Miranti, C. K., Warfel, N. A., Garcia, J. G. N., Arif-Tiwari, H. & Cress, A. E., Sep 15 2019, In : Cancer Research. 79, 18, p. 4703-4714 12 p.

Research output: Contribution to journalArticle

2011

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter

Pendyala, S., Moitra, J., Kalari, S., Kleeberger, S. R., Zhao, Y., Reddy, S. P., Garcia, J. G. N. & Natarajan, V., Jun 15 2011, In : Free Radical Biology and Medicine. 50, 12, p. 1749-1759 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
2014

Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in Hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells

Usatyuk, P. V., Fu, P., Mohan, V., Epshtein, Y., Jacobson, J. R., Gomez-Cambronero, J., Wary, K. K., Bindokas, V., Dudek, S. M., Salgia, R., Garcia, J. G. N. & Natarajan, V., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 13476-13491 16 p.

Research output: Contribution to journalArticle

42 Scopus citations

Nontuberculous mycobacterial disease mortality in the United States, 1999-2010: A population-based comparative study

Mirsaeidi, M., Machado, R. F., Garcia, J. G. N. & Schraufnagel, D. E., Mar 14 2014, In : PloS one. 9, 3, e91879.

Research output: Contribution to journalArticle

81 Scopus citations

The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis

Huang, L. S., Mathew, B., Li, H., Zhao, Y., Ma, S. F., Noth, I., Reddy, S. P., Harijith, A., Usatyuk, P. V., Berdyshev, E. V., Kaminski, N., Zhou, T., Zhang, W., Zhang, Y., Rehman, J., Kotha, S. R., Gurney, T. O., Parinandi, N. L., Lussier, Y. A., Garcia, J. G. N. & 1 others, Natarajan, V., Jun 1 2014, In : American journal of respiratory and critical care medicine. 189, 11, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin

Chen, W., Sharma, R., Rizzo, A. N., Siegler, J. H., Garcia, J. G. N. & Jacobson, J. R., Feb 1 2014, In : American journal of respiratory cell and molecular biology. 50, 2, p. 328-336 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2017

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Palumbo, S., Shin, Y. J., Ahmad, K., Desai, A., Quijada, H., Mohamed, M., Knox, A., Sammani, S., Colson, B. A., Wang, T., Garcia, J. G. N. & Hecker, L., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L297-L308

Research output: Contribution to journalArticle

10 Scopus citations
2015

Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress

Chen, W., Epshtein, Y., Ni, X., Dull, R. O., Cress, A. E., Garcia, J. G. N. & Jacobson, J. R., Nov 17 2015, In : Scientific Reports. 5, 16529.

Research output: Contribution to journalArticle

13 Scopus citations
2018

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18

Gross, C. M., Kellner, M., Wang, T., Lu, Q., Sun, X., Zemskov, E. A., Noonepalle, S., Kangath, A., Kumar, S., Gonzalez-Garay, M., Desai, A., Aggarwal, S., Gorshkov, B., Klinger, C., Verin, A. D., Catravas, J. D., Jacobson, J. R., Yuan, J. X. J., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 614-624 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Endothelial cell signaling and ventilator-induced lung injury: Molecular mechanisms, genomic analyses, and therapeutic targets

Wang, T., Gross, C., Desai, A., Zemskov, E., Wu, X., Garcia, A. N., Jacobson, J. R., Yuan, J., Garcia, J. GN. & Black, S. M., Apr 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, p. L452-L476

Research output: Contribution to journalReview article

27 Scopus citations
2014

Mechanistic insights and characterization of sickle cell disease-associated cardiomyopathy

Desai, A. A., Patel, A. R., Ahmad, H., Groth, J. V., Thiruvoipati, T., Turner, K., Yodwut, C., Czobor, P., Artz, N., MacHado, R. F., Garcia, J. G. N. & Lang, R. M., Jul 2014, In : Circulation: Cardiovascular Imaging. 7, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Excessive mechanical stress increases HMGB1 expression in human lung microvascular endothelial cells via STAT3

Wolfson, R. K., Mapes, B. & Garcia, J. G. N., Mar 2014, In : Microvascular Research. 92, p. 50-55 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016
9 Scopus citations
2017
13 Scopus citations
2011

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement

Adyshev, D. M., Moldobaeva, N. K., Elangovan, V. R., Garcia, J. G. N. & Dudek, S. M., Dec 1 2011, In : Cellular Signalling. 23, 12, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Integrating microRNAs into a system biology approach to acute lung injury

Zhou, T., Garcia, J. G. N. & Zhang, W., Apr 2011, In : Translational Research. 157, 4, p. 180-190 11 p.

Research output: Contribution to journalReview article

68 Scopus citations
2017

Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A. A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J. X. J., Catravas, J. D., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., Jan 1 2017, In : Free Radical Biology and Medicine. 102, p. 217-228 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Audrito, V., Serra, S., Brusa, D., Mazzola, F., Arruga, F., Vaisitti, T., Coscia, M., Maffei, R., Rossi, D., Wang, T., Inghirami, G., Rizzi, M., Gaidano, G., Garcia, J. G. N., Wolberger, C., Raffaelli, N. & Deaglio, S., Jan 1 2015, In : Blood. 125, 1, p. 111-123 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Body temperature and mortality in patients with acute respiratory distress syndrome

The National heart, Lung, and Blood Institute Acute Respiratory distress syndrome Network, 2015, In : American Journal of Critical Care. 24, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

GADD45a promoter regulation by a functional genetic variant associated with acute lung injury

Mitra, S., Wade, M. S., Sun, X., Moldobaeva, N., Flores, C., Shwu-Fan, M., Zhang, W., Garcia, J. G. N. & Jacobson, J. R., Jun 18 2014, In : PloS one. 9, 6, e100169.

Research output: Contribution to journalArticle

8 Scopus citations
2019

Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension

Wang, Z., Yang, K., Zheng, Q., Zhang, C., Tang, H., Babicheva, A., Jiang, Q., Li, M., Chen, Y., Carr, S. G., Wu, K., Zhang, Q., Balistrieri, A., Wang, C., Song, S., Ayon, R. J., Desai, A., Black, S. M., Garcia, J. G. N., Makino, A. & 3 others, Yuan, J. X. J., Lu, W. & Wang, J., Jan 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 1, p. L216-L228

Research output: Contribution to journalArticle

4 Scopus citations
2018

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Wang, T., Brown, M. E., Kelly, G. T., Camp, S. M., Mascarenhas, J. B., Sun, X., Dudek, S. M. & Garcia, J. GN., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

4 Scopus citations

Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension

Whitaker, M. E., Nair, V., Sinari, S., Dherange, P. A., Natarajan, B., Trutter, L., Brittain, E. L., Hemnes, A. R., Austin, E. D., Patel, K., Black, S. M., Garcia, J. GN., Yuan, MD PhD, J. X., Vanderpool, R. R., Rischard, F., Makino, A., Bedrick, E. J. & Desai, A., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

4 Scopus citations
2020

Surfing the right ventricular pressure waveform: methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization

Vanderpool, R. R., Puri, R., Osorio, A., Wickstrom, K., Desai, A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Rischard, F. P., Jan 1 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2015

Sp1-mediated nonmuscle myosin light chain kinase expression and enhanced activity in vascular endothelial growth factor–induced vascular permeability

Shimizua, Y., Campa, S. M., Sun, X., Zhou, T., Wang, T. & Garcia, J. GN., Oct 23 2015, In : Pulmonary Circulation. 5, 4, p. 707-715 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2019

Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes

Casanova, N., Zhou, T., Gonzalez-Garay, M. L., Rosas, I. O., Goldberg, H. J., Ryter, S. W., Collard, H. R., El-Chemaly, S., Flaherty, K. R., Hunninghake, G. M., Lasky, J. A., Lederer, D. J., Machado, R. F., Martinez, F. J., Noth, I., Raghu, G., Choi, A. M. K. & Garcia, J. G. N., Dec 1 2019, In : Scientific reports. 9, 1, 14802.

Research output: Contribution to journalArticle

Open Access
2012

Host response signature to staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response

Frank, K. M., Zhou, T., Moreno-Vinasco, L., Hollett, B., Garcia, J. G. N. & Wardenburg, J. B., Sep 1 2012, In : Infection and Immunity. 80, 9, p. 3161-3169 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

Evaluation of a reliable and cost-effective method of DNA isolation for mouse genotyping

Sysol, J. R., Kempf, C., Helton, M. N., Dong, Y., Zhu, D., Sun, H., Garcia, J. G. N., Machado, R. F. & Chen, J., Jan 1 2013, In : Biotechnology Letters. 35, 4, p. 509-514 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans

Lynn, H., Sun, X., Ayshiev, D., Siegler, J. H., Rizzo, A. N., Karnes, J. H., Garay, M. G., Wang, T., Casanova, N., Camp, S. M., Ellis, N. A. & Garcia, J. G. N., Aug 2018, In : PloS one. 13, 8, e0200916.

Research output: Contribution to journalArticle

2 Scopus citations

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H., Babicheva, A., McDermott, K. M., Gu, Y., Ayon, R. J., Song, S., Wang, Z., Gupta, A., Zhou, T., Sun, X., Dash, S., Wang, Z., Balistrieri, A., Zheng, Q., Cordery, A. G., Desai, A. A., Rischard, F., Khalpey, Z., Wang, J., Black, S. M. & 3 others, Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Feb 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

37 Scopus citations

An update on sphingosine-1-phosphate receptor 1 modulators

Marciniak, A., Camp, S. M., Garcia, J. GN. & Polt, R. L., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations
2013

TGFβ signaling induces expression of Gadd45b in retinal ganglion cells

Liu, B., Sun, X., Suyeoka, G., Garcia, J. G. N. & Leiderman, Y. I., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 1061-1069 9 p.

Research output: Contribution to journalArticle

9 Scopus citations