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2020
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor
Zhou, Y., Mowlazadeh Haghighi, S., Liu, Z., Wang, L., Hruby, V. J. & Cai, M., Oct 9 2020, In: ACS Pharmacology and Translational Science. 3, 5, p. 921-930 10 p.Research output: Contribution to journal › Article › peer-review
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Development of novel frog-skin peptide scaffolds with selectivity towards melanocortin receptor subtypes
Malik, U., Chan, L. Y., Cai, M., Hruby, V. J., Kaas, Q., Daly, N. L. & Craik, D. J., 2020, (Accepted/In press) In: Peptide Science.Research output: Contribution to journal › Article › peer-review
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Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice
Kadiri, J. J., Thapa, K., Kaipio, K., Cai, M., Hruby, V. J. & Rinne, P., Aug 5 2020, In: European Journal of Pharmacology. 880, 173186.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Development of N-acetylated dipalmitoyl-S-glyceryl cysteine analogs as efficient TLR2/TLR6 agonists
Zhou, Y., Banday, A. H., Hruby, V. J. & Cai, M., Sep 27 2019, In: Molecules. 24, 19, 3512.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction
Hruby, V. J., Jun 1 2019, In: Peptides. 116, p. 63-67 5 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands
Wu, Z. & Hruby, V. J., Oct 22 2019, In: ACS Omega. 4, 17, p. 17457-17476 20 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2018
Correction: Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation (Journal of Medicinal Chemistry (2017) 60 (9320-9329) DOI: 10.1021/acs.jmedchem.7b01295)
Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M., Oct 11 2018, In: Journal of Medicinal Chemistry. 61, 19, p. 8945 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors
Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. & Lee, Y. S., Jul 23 2018, In: Bioorganic and Medicinal Chemistry. 26, 12, p. 3664-3667 4 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors
Merlino, F., Zhou, Y., Cai, M., Carotenuto, A., Yousif, A. M., Brancaccio, D., Di Maro, S., Zappavigna, S., Limatola, A., Novellino, E., Grieco, P. & Hruby, V. J., May 10 2018, In: Journal of Medicinal Chemistry. 61, 9, p. 4263-4269 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1
Durek, T., Cromm, P. M., White, A. M., Schroeder, C. I., Kaas, Q., Weidmann, J., Ahmad Fuaad, A., Cheneval, O., Harvey, P. J., Daly, N. L., Zhou, Y., Dellsén, A., Österlund, T., Larsson, N., Knerr, L., Bauer, U., Kessler, H., Cai, M., Hruby, V. J., Plowright, A. T. & 1 others, , Apr 26 2018, In: Journal of Medicinal Chemistry. 61, 8, p. 3674-3684 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., Yamamoto, T., Hruby, V. J., Khanna, R., Largent-Milnes, T. M. & Vanderah, T. W., Aug 1 2018, In: Molecular Psychiatry. 23, 8, p. 1745-1755 11 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice
Eerola, K., Virtanen, S., Vähätalo, L., Ailanen, L., Cai, M., Hruby, V., Savontaus, M. & Savontaus, E., Oct 1 2018, In: Journal of Endocrinology. 239, 1, p. 19-31 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence
Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J. & Nichols, R. A., Jan 2018, In: Journal of neurochemistry. 144, 2, p. 201-217 17 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation
Mowlazadeh Haghighi, S., Zhou, Y., Dai, J., Sawyer, J. R., Hruby, V. J. & Cai, M., May 10 2018, In: European journal of medicinal chemistry. 151, p. 815-823 9 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice
Olson, K. M., Keresztes, A., Tashiro, J. K., Daconta, L. V., Hruby, V. J. & Streicher, J. M., Jul 26 2018, In: Journal of Medicinal Chemistry. 61, 14, p. 6075-6086 12 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2017
Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation
Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M., Nov 22 2017, In: Journal of Medicinal Chemistry. 60, 22, p. 9320-9329 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers
Stefanucci, A., Lei, W., Hruby, V. J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J. M. & Mollica, A., Jun 1 2017, In: Future Medicinal Chemistry. 9, 9, p. 859-869 11 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages
Rinne, P., Rami, M., Nuutinen, S., Santovito, D., Van Der Vorst, E. P. C., Guillamat-Prats, R., Lyytikäinen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimäki, T., Weber, C. & Steffens, S., Jul 4 2017, In: Circulation. 136, 1, p. 83-97 15 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics
Remesic, M., Hruby, V. J., Porreca, F. & Lee, Y. S., Jun 21 2017, In: ACS Chemical Neuroscience. 8, 6, p. 1147-1158 12 p.Research output: Contribution to journal › Review article › peer-review
20 Scopus citations -
Reversed-phase high-performance liquid chromatography for the separation of peptide diastereoisomers
Hruby, V. J., Kawasaki, A. & Toth, G., Jan 1 2017, High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation. CRC Press, p. 379-388 10 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists
Cai, M., Marelli, U. K., Mertz, B., Beck, J. G., Opperer, F., Rechenmacher, F., Kessler, H. & Hruby, V. J., Aug 15 2017, In: Biochemistry. 56, 32, p. 4201-4209 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain
Vardanyan, R. S., Cain, J. P., Haghighi, S. M., Kumirov, V. K., McIntosh, M. I., Sandweiss, A. J., Porreca, F. & Hruby, V. J., 2017, In: Journal of Heterocyclic Chemistry. 54, 2, p. 1228-1235 8 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2016
Cyclic non-opioid dynorphin A analogues for the bradykinin receptors
Lee, Y. S., Remesic, M., Ramos-Colon, C., Hall, S. M., Kuzmin, A., Rankin, D., Porreca, F., Lai, J. & Hruby, V. J., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5513-5516 4 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Cyclic opioid peptides
Remesic, M., Lee, Y. S. & Hruby, V. J., Apr 1 2016, In: Current medicinal chemistry. 23, 13, p. 1288-1303 16 p.Research output: Contribution to journal › Review article › peer-review
20 Scopus citations -
Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors
Hruby, V. J., Nov 1 2016, In: Biopolymers. 106, 6, p. 884-888 5 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Design of cyclized selective melanotropins
Cai, M. & Hruby, V. J., Nov 1 2016, In: Biopolymers. 106, 6, p. 876-883 8 p.Research output: Contribution to journal › Review article › peer-review
12 Scopus citations -
Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands
Deekonda, S., Rankin, D., Davis, P., Lai, J., Vanderah, T. W., Porecca, F. & Hruby, V. J., Jan 15 2016, In: Bioorganic and Medicinal Chemistry. 24, 2, p. 85-91 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain
Hall, S. M., LeBaron, L., Ramos-Colon, C., Qu, C., Xie, J. Y., Porreca, F., Lai, J., Lee, Y. S. & Hruby, V. J., Dec 21 2016, In: ACS Chemical Neuroscience. 7, 12, p. 1746-1752 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Dynorphin A analogs for the treatment of chronic neuropathic pain
Hall, S. M., Lee, Y. S. & Hruby, V. J., Feb 2016, In: Future Medicinal Chemistry. 8, 2, p. 165-177 13 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations
Deekonda, S., Cole, J., Sunna, S., Rankin, D., Largent-Milnes, T. M., Davis, P., Bassirirad, N. M., Lai, J., Vanderah, T. W., Porecca, F. & Hruby, V. J., Jan 1 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 1, p. 222-227 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Enkephalin-fentanyl multifunctional opioids as potential neuroprotectants for ischemic stroke treatment
Islam, M. R., Yang, L., Lee, Y. S., Hruby, V. J., Karamyan, V. T. & Abbruscato, T. J., Nov 1 2016, In: Current Pharmaceutical Design. 22, 42, p. 6459-6468 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the ΰ Opioid Receptor
Ramos-Colon, C. N., Lee, Y. S., Remesic, M., Hall, S. M., Lavigne, J., Davis, P., Sandweiss, A. J., McIntosh, M. I., Hanson, J., Largent-Milnes, T. M., Vanderah, T. W., Streicher, J., Porreca, F. & Hruby, V. J., Nov 23 2016, In: Journal of Medicinal Chemistry. 59, 22, p. 10291-10298 8 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
The melanocortin receptor system: A target for multiple degenerative diseases
Cai, M. & Hruby, V. J., Aug 1 2016, In: Current Protein and Peptide Science. 17, 5, p. 488-496 9 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5
Huynh, A. S., Estrella, V., Stark, V. E., Cohen, A. S., Chen, T., Casagni, T. J., Josan, J. S., Lloyd, M. C., Johnson, J., Kim, J., Hruby, V. J., Vagner, J. & Morse, D. L., Feb 1 2016, In: Molecular Pharmaceutics. 13, 2, p. 534-544 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors
Lee, Y. S., Kupp, R., Remesic, M. V., Ramos-Colon, C., Hall, SM., Chan, C., Rankin, D., Lai, J., Porreca, F. & Hruby, V. J., Oct 1 2016, In: Chemical Biology and Drug Design. p. 615-619 5 p.Research output: Contribution to journal › Letter › peer-review
2 Scopus citations