2019
Development of N-acetylated dipalmitoyl-S-glyceryl cysteine analogs as efficient TLR2/TLR6 agonists
Zhou, Y., Banday, A. H., Hruby, V. J. & Cai, M., Sep 27 2019, In : Molecules. 24, 19, 3512.Research output: Contribution to journal › Article
Open Access
Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction
Hruby, V. J., Jun 1 2019, In : Peptides. 116, p. 63-67 5 p.Research output: Contribution to journal › Review article
2
Scopus
citations
Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands
Wu, Z. & Hruby, V. J., Oct 22 2019, In : ACS Omega. 4, 17, p. 17457-17476 20 p.Research output: Contribution to journal › Article
Open Access
2018
Correction: Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation (Journal of Medicinal Chemistry (2017) 60 (9320-9329) DOI: 10.1021/acs.jmedchem.7b01295)
Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, 1 p.Research output: Contribution to journal › Comment/debate
Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors
Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. J. & Lee, Y. S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.Research output: Contribution to journal › Article
1
Scopus
citations
Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors
Merlino, F., Zhou, Y., Cai, M., Carotenuto, A., Yousif, A. M., Brancaccio, D., Di Maro, S., Zappavigna, S., Limatola, A., Novellino, E., Grieco, P. & Hruby, V. J., May 10 2018, In : Unknown Journal. 61, 9, p. 4263-4269 7 p.Research output: Contribution to journal › Article
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1
Durek, T., Cromm, P. M., White, A. M., Schroeder, C. I., Kaas, Q., Weidmann, J., Ahmad Fuaad, A., Cheneval, O., Harvey, P. J., Daly, N. L., Zhou, Y., Dellsén, A., Österlund, T., Larsson, N., Knerr, L., Bauer, U., Kessler, H., Cai, M., Hruby, V. J., Plowright, A. T. & 1 others, , Apr 26 2018, In : Journal of Medicinal Chemistry. 61, 8, p. 3674-3684 11 p.Research output: Contribution to journal › Article
6
Scopus
citations
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., Yamamoto, T., Hruby, V. J., Khanna, R., Largent-Milnes, T. M. & Vanderah, T. W., Aug 1 2018, In : Molecular Psychiatry. 23, 8, p. 1745-1755 11 p.Research output: Contribution to journal › Article
6
Scopus
citations
Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice
Eerola, K., Virtanen, S., Vähätalo, L., Ailanen, L., Cai, M., Hruby, V. J., Savontaus, M. & Savontaus, E., Oct 1 2018, In : Journal of Endocrinology. 239, 1, p. 19-31 13 p.Research output: Contribution to journal › Article
2
Scopus
citations
Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence
Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J. & Nichols, R. A., Jan 1 2018, In : Journal of Neurochemistry. 144, 2, p. 201-217 17 p.Research output: Contribution to journal › Article
7
Scopus
citations
Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation
Mowlazadeh Haghighi, S., Zhou, Y., Dai, J., Sawyer, J. R., Hruby, V. J. & Cai, M., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 815-823 9 p.Research output: Contribution to journal › Article
3
Scopus
citations
Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice
Olson, K. M., Keresztes, A., Tashiro, J. K., Daconta, L. V., Hruby, V. J. & Streicher, J. M., Jul 26 2018, In : Journal of Medicinal Chemistry. 61, 14, p. 6075-6086 12 p.Research output: Contribution to journal › Article
3
Scopus
citations
2017
Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation
Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M., Nov 22 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9320-9329 10 p.Research output: Contribution to journal › Article
7
Scopus
citations
Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers
Stefanucci, A., Lei, W., Hruby, V. J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J. M. & Mollica, A., Jun 1 2017, In : Future Medicinal Chemistry. 9, 9, p. 859-869 11 p.Research output: Contribution to journal › Article
13
Scopus
citations
Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages
Rinne, P., Rami, M., Nuutinen, S., Santovito, D., Van Der Vorst, E. P. C., Guillamat-Prats, R., Lyytikäinen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimäki, T., Weber, C. & Steffens, S., Jul 4 2017, In : Circulation. 136, 1, p. 83-97 15 p.Research output: Contribution to journal › Article
15
Scopus
citations
Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics
Remesic, M., Hruby, V. J., Porreca, F. & Lee, Y. S., Jun 21 2017, In : ACS Chemical Neuroscience. 8, 6, p. 1147-1158 12 p.Research output: Contribution to journal › Review article
11
Scopus
citations
Reversed-phase high-performance liquid chromatography for the separation of peptide diastereoisomers
Hruby, V. J., Kawasaki, A. & Toth, G., Jan 1 2017, High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation. CRC Press, p. 379-388 10 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1
Scopus
citations
Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists
Cai, M., Marelli, U. K., Mertz, B., Beck, J. G., Opperer, F., Rechenmacher, F., Kessler, H. & Hruby, V. J., Aug 15 2017, In : Biochemistry. 56, 32, p. 4201-4209 9 p.Research output: Contribution to journal › Article
2
Scopus
citations
2016
Cyclic non-opioid dynorphin A analogues for the bradykinin receptors
Lee, Y. S., Remesic, M., Ramos-Colon, C., Hall, S. M., Kuzmin, A., Rankin, D., Porreca, F., Lai, J. & Hruby, V. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5513-5516 4 p.Research output: Contribution to journal › Article
3
Scopus
citations
Cyclic opioid peptides
Remesic, M., Lee, Y. S. & Hruby, V. J., Apr 1 2016, In : Current Medicinal Chemistry. 23, 13, p. 1288-1303 16 p.Research output: Contribution to journal › Review article
15
Scopus
citations
Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors
Hruby, V. J., Nov 1 2016, In : Biopolymers. 106, 6, p. 884-888 5 p.Research output: Contribution to journal › Article
8
Scopus
citations
Design of cyclized selective melanotropins
Cai, M. & Hruby, V. J., Nov 1 2016, In : Biopolymers. 106, 6, p. 876-883 8 p.Research output: Contribution to journal › Review article
9
Scopus
citations
Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands
Deekonda, S., Rankin, D., Davis, P., Lai, J., Vanderah, T. W., Porecca, F. & Hruby, V. J., Jan 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 2, p. 85-91 7 p.Research output: Contribution to journal › Article
2
Scopus
citations
Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain
Hall, S. M., LeBaron, L., Ramos-Colon, C., Qu, C., Xie, J. Y., Porreca, F., Lai, J., Lee, Y. S. & Hruby, V. J., Dec 21 2016, In : ACS Chemical Neuroscience. 7, 12, p. 1746-1752 7 p.Research output: Contribution to journal › Article
5
Scopus
citations
Dynorphin A analogs for the treatment of chronic neuropathic pain
Hall, S. M., Lee, Y. S. & Hruby, V. J., Feb 1 2016, In : Future Medicinal Chemistry. 8, 2, p. 165-177 13 p.Research output: Contribution to journal › Article
3
Scopus
citations
Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations
Deekonda, S., Cole, J., Sunna, S., Rankin, D., Largent-Milnes, T. M., Davis, P., Bassirirad, N. M., Lai, J., Vanderah, T. W., Porecca, F. & Hruby, V. J., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 1, p. 222-227 6 p.Research output: Contribution to journal › Article
3
Scopus
citations
Enkephalin-fentanyl multifunctional opioids as potential neuroprotectants for ischemic stroke treatment
Islam, M. R., Yang, L., Lee, Y. S., Hruby, V. J., Karamyan, V. T. & Abbruscato, T. J., Nov 1 2016, In : Current Pharmaceutical Design. 22, 42, p. 6459-6468 10 p.Research output: Contribution to journal › Article
9
Scopus
citations
Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the ΰ Opioid Receptor
Ramos-Colon, C. N., Lee, Y. S., Remesic, M., Hall, S. M., Lavigne, J., Davis, P., Sandweiss, A. J., McIntosh, M. I., Hanson, J., Largent-Milnes, T. M., Vanderah, T. W., Streicher, J., Porreca, F. & Hruby, V. J., Nov 23 2016, In : Journal of Medicinal Chemistry. 59, 22, p. 10291-10298 8 p.Research output: Contribution to journal › Article
5
Scopus
citations
Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain
Vardanyan, R. S., Cain, J. P., Haghighi, S. M., Kumirov, V. K., Mcintosh, M. I., Sandweiss, A. J., Porreca, F. & Hruby, V. J., 2016, (Accepted/In press) In : Journal of Heterocyclic Chemistry.Research output: Contribution to journal › Article
3
Scopus
citations
The melanocortin receptor system: A target for multiple degenerative diseases
Cai, M. & Hruby, V. J., Aug 1 2016, In : Current Protein and Peptide Science. 17, 5, p. 488-496 9 p.Research output: Contribution to journal › Article
12
Scopus
citations
Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5
Huynh, A. S., Estrella, V., Stark, V. E., Cohen, A. S., Chen, T., Casagni, T. J., Josan, J. S., Lloyd, M. C., Johnson, J., Kim, J., Hruby, V. J., Vagner, J. & Morse, D. L., Feb 1 2016, In : Molecular Pharmaceutics. 13, 2, p. 534-544 11 p.Research output: Contribution to journal › Article
6
Scopus
citations
Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors
Lee, Y. S., Kupp, R., Remesic, M. V., Ramos-Colon, C., Hall, SM., Chan, C., Rankin, D., Lai, J., Porreca, F. & Hruby, V. J., Oct 1 2016, In : Chemical Biology and Drug Design. p. 615-619 5 p.Research output: Contribution to journal › Letter
2
Scopus
citations