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  • Victor J Hruby
2019

Development of N-acetylated dipalmitoyl-S-glyceryl cysteine analogs as efficient TLR2/TLR6 agonists

Zhou, Y., Banday, A. H., Hruby, V. J. & Cai, M., Sep 27 2019, In : Molecules. 24, 19, 3512.

Research output: Contribution to journalArticle

Open Access

Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

Hruby, V. J., Jun 1 2019, In : Peptides. 116, p. 63-67 5 p.

Research output: Contribution to journalReview article

2 Scopus citations

Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands

Wu, Z. & Hruby, V. J., Oct 22 2019, In : ACS Omega. 4, 17, p. 17457-17476 20 p.

Research output: Contribution to journalArticle

Open Access
2018

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. J. & Lee, Y. S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

1 Scopus citations

Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors

Merlino, F., Zhou, Y., Cai, M., Carotenuto, A., Yousif, A. M., Brancaccio, D., Di Maro, S., Zappavigna, S., Limatola, A., Novellino, E., Grieco, P. & Hruby, V. J., May 10 2018, In : Unknown Journal. 61, 9, p. 4263-4269 7 p.

Research output: Contribution to journalArticle

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, T., Cromm, P. M., White, A. M., Schroeder, C. I., Kaas, Q., Weidmann, J., Ahmad Fuaad, A., Cheneval, O., Harvey, P. J., Daly, N. L., Zhou, Y., Dellsén, A., Österlund, T., Larsson, N., Knerr, L., Bauer, U., Kessler, H., Cai, M., Hruby, V. J., Plowright, A. T. & 1 others, Craik, D. J., Apr 26 2018, In : Journal of Medicinal Chemistry. 61, 8, p. 3674-3684 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., Yamamoto, T., Hruby, V. J., Khanna, R., Largent-Milnes, T. M. & Vanderah, T. W., Aug 1 2018, In : Molecular Psychiatry. 23, 8, p. 1745-1755 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice

Eerola, K., Virtanen, S., Vähätalo, L., Ailanen, L., Cai, M., Hruby, V. J., Savontaus, M. & Savontaus, E., Oct 1 2018, In : Journal of Endocrinology. 239, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence

Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J. & Nichols, R. A., Jan 1 2018, In : Journal of Neurochemistry. 144, 2, p. 201-217 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation

Mowlazadeh Haghighi, S., Zhou, Y., Dai, J., Sawyer, J. R., Hruby, V. J. & Cai, M., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 815-823 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice

Olson, K. M., Keresztes, A., Tashiro, J. K., Daconta, L. V., Hruby, V. J. & Streicher, J. M., Jul 26 2018, In : Journal of Medicinal Chemistry. 61, 14, p. 6075-6086 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation

Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M., Nov 22 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9320-9329 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers

Stefanucci, A., Lei, W., Hruby, V. J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J. M. & Mollica, A., Jun 1 2017, In : Future Medicinal Chemistry. 9, 9, p. 859-869 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages

Rinne, P., Rami, M., Nuutinen, S., Santovito, D., Van Der Vorst, E. P. C., Guillamat-Prats, R., Lyytikäinen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimäki, T., Weber, C. & Steffens, S., Jul 4 2017, In : Circulation. 136, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Remesic, M., Hruby, V. J., Porreca, F. & Lee, Y. S., Jun 21 2017, In : ACS Chemical Neuroscience. 8, 6, p. 1147-1158 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

Reversed-phase high-performance liquid chromatography for the separation of peptide diastereoisomers

Hruby, V. J., Kawasaki, A. & Toth, G., Jan 1 2017, High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation. CRC Press, p. 379-388 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists

Cai, M., Marelli, U. K., Mertz, B., Beck, J. G., Opperer, F., Rechenmacher, F., Kessler, H. & Hruby, V. J., Aug 15 2017, In : Biochemistry. 56, 32, p. 4201-4209 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors

Lee, Y. S., Remesic, M., Ramos-Colon, C., Hall, S. M., Kuzmin, A., Rankin, D., Porreca, F., Lai, J. & Hruby, V. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5513-5516 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cyclic opioid peptides

Remesic, M., Lee, Y. S. & Hruby, V. J., Apr 1 2016, In : Current Medicinal Chemistry. 23, 13, p. 1288-1303 16 p.

Research output: Contribution to journalReview article

15 Scopus citations
8 Scopus citations

Design of cyclized selective melanotropins

Cai, M. & Hruby, V. J., Nov 1 2016, In : Biopolymers. 106, 6, p. 876-883 8 p.

Research output: Contribution to journalReview article

9 Scopus citations
2 Scopus citations

Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain

Hall, S. M., LeBaron, L., Ramos-Colon, C., Qu, C., Xie, J. Y., Porreca, F., Lai, J., Lee, Y. S. & Hruby, V. J., Dec 21 2016, In : ACS Chemical Neuroscience. 7, 12, p. 1746-1752 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dynorphin A analogs for the treatment of chronic neuropathic pain

Hall, S. M., Lee, Y. S. & Hruby, V. J., Feb 1 2016, In : Future Medicinal Chemistry. 8, 2, p. 165-177 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations

Deekonda, S., Cole, J., Sunna, S., Rankin, D., Largent-Milnes, T. M., Davis, P., Bassirirad, N. M., Lai, J., Vanderah, T. W., Porecca, F. & Hruby, V. J., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 1, p. 222-227 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enkephalin-fentanyl multifunctional opioids as potential neuroprotectants for ischemic stroke treatment

Islam, M. R., Yang, L., Lee, Y. S., Hruby, V. J., Karamyan, V. T. & Abbruscato, T. J., Nov 1 2016, In : Current Pharmaceutical Design. 22, 42, p. 6459-6468 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the ΰ Opioid Receptor

Ramos-Colon, C. N., Lee, Y. S., Remesic, M., Hall, S. M., Lavigne, J., Davis, P., Sandweiss, A. J., McIntosh, M. I., Hanson, J., Largent-Milnes, T. M., Vanderah, T. W., Streicher, J., Porreca, F. & Hruby, V. J., Nov 23 2016, In : Journal of Medicinal Chemistry. 59, 22, p. 10291-10298 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain

Vardanyan, R. S., Cain, J. P., Haghighi, S. M., Kumirov, V. K., Mcintosh, M. I., Sandweiss, A. J., Porreca, F. & Hruby, V. J., 2016, (Accepted/In press) In : Journal of Heterocyclic Chemistry.

Research output: Contribution to journalArticle

3 Scopus citations

The melanocortin receptor system: A target for multiple degenerative diseases

Cai, M. & Hruby, V. J., Aug 1 2016, In : Current Protein and Peptide Science. 17, 5, p. 488-496 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5

Huynh, A. S., Estrella, V., Stark, V. E., Cohen, A. S., Chen, T., Casagni, T. J., Josan, J. S., Lloyd, M. C., Johnson, J., Kim, J., Hruby, V. J., Vagner, J. & Morse, D. L., Feb 1 2016, In : Molecular Pharmaceutics. 13, 2, p. 534-544 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors

Lee, Y. S., Kupp, R., Remesic, M. V., Ramos-Colon, C., Hall, SM., Chan, C., Rankin, D., Lai, J., Porreca, F. & Hruby, V. J., Oct 1 2016, In : Chemical Biology and Drug Design. p. 615-619 5 p.

Research output: Contribution to journalLetter

2 Scopus citations