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  • Joe GN Garcia
2020

Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis

Badagliacca, R., Rischard, F., Papa, S., Kubba, S., Vanderpool, R., Yuan, J. X. J., Garcia, J. G. N., Airhart, S., Poscia, R., Pezzuto, B., Manzi, G., Miotti, C., Luongo, F., Scoccia, G., Sciomer, S., Torre, RN, MSN, R., Fedele, F. & Vizza, C. D., Jan 1 2020, (Accepted/In press) In : Journal of Heart and Lung Transplantation.

Research output: Contribution to journalArticle

Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

Brazee, P. L., Morales-Nebreda, L., Magnani, N. D., Garcia, J. G. N., Misharin, A. V., Ridge, K. M., Budinger, G. R. S., Iwai, K., Dada, L. A. & Sznajder, J. I., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1301-1314 14 p.

Research output: Contribution to journalArticle

Open Access

Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

Camp, S. M., Marciniak, A., Chiang, E. T., Garcia, A. N., Bittman, R., Polt, R., Perez, R. G., Dudek, S. M. & Garcia, J. G. N., Jan 1 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticle

Open Access

Surfing the right ventricular pressure waveform: methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization

Vanderpool, R. R., Puri, R., Osorio, A., Wickstrom, K., Desai, A. A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Rischard, F. P., Jan 1 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticle

Open Access
2019

Development of a biomarker mortality risk model in acute respiratory distress syndrome

Bime, C., Casanova, N., Oita, R. C., Ndukum, J., Lynn, H., Camp, S. M., Lussier, Y., Abraham, I., Carter, D., Miller, E. J., Mekontso-Dessap, A., Downs, C. A. & Garcia, J. G. N., Dec 16 2019, In : Critical Care. 23, 1, 410.

Research output: Contribution to journalArticle

Open Access

Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension

Wang, Z., Yang, K., Zheng, Q., Zhang, C., Tang, H., Babicheva, A., Jiang, Q., Li, M., Chen, Y., Carr, S. G., Wu, K., Zhang, Q., Balistrieri, A., Wang, C., Song, S., Ayon, R. J., Desai, A., Black, S. M., Garcia, J. G. N., Makino, A. & 3 others, Yuan, J. X. J., Lu, W. & Wang, J., Jan 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 1, p. L216-L228

Research output: Contribution to journalArticle

3 Scopus citations

Gene editing of α6 integrin inhibits muscle invasive networks and increases cell-cell biophysical properties in prostate cancer

Rubenstein, C. S., Gard, J. M. C., Wang, M., McGrath, J. E., Ingabire, N., Hinton, J. P., Marr, K. D., Simpson, S. J., Nagle, R. B., Miranti, C. K., Warfel, N. A., Garcia, J. G. N., Arif-Tiwari, H. & Cress, A. E., Sep 15 2019, In : Cancer Research. 79, 18, p. 4703-4714 12 p.

Research output: Contribution to journalArticle

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium & US PAH Biobank Consortium, Mar 1 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality

Lynn, H., Sun, X., Casanova, N., Gonzales-Garay, M., Bime, C. & Garcia, J. G. N., Nov 10 2019, In : Antioxidants and Redox Signaling. 31, 14, p. 1027-1052 26 p.

Research output: Contribution to journalReview article

Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions

Wang, M., Hinton, J. P., Gard, J. M. C., Garcia, J. GN., Knudsen, B. S., Nagle, R. B. & Cress, A. E., Mar 21 2019, In : Molecular biology of the cell. 30, 7, p. 838-850 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes

Casanova, N., Zhou, T., Gonzalez-Garay, M. L., Rosas, I. O., Goldberg, H. J., Ryter, S. W., Collard, H. R., El-Chemaly, S., Flaherty, K. R., Hunninghake, G. M., Lasky, J. A., Lederer, D. J., Machado, R. F., Martinez, F. J., Noth, I., Raghu, G., Choi, A. M. K. & Garcia, J. G. N., Dec 1 2019, In : Scientific reports. 9, 1, 14802.

Research output: Contribution to journalArticle

Open Access

Tissue ACE phenotyping in lung cancer

Danilov, S. M., Metzger, R., Klieser, E., Sotlar, K., Trakht, I. N. & Garcia, J. G. N., Jan 1 2019, In : PloS one. 14, 12, e0226553.

Research output: Contribution to journalArticle

Open Access
2018

An update on sphingosine-1-phosphate receptor 1 modulators

Marciniak, A., Camp, S. M., Garcia, J. GN. & Polt, R. L., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2 Scopus citations

A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis

Rosas, I. O., Goldberg, H. J., Collard, H. R., El-Chemaly, S., Flaherty, K., Hunninghake, G. M., Lasky, J. A., Lederer, D. J., Machado, R., Martinez, F. J., Maurer, R., Teller, D., Noth, I., Peters, E., Raghu, G., Garcia, J. GN. & Choi, A. M. K., Jan 1 2018, In : Chest. 153, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension

Whitaker, M. E., Nair, V., Sinari, S., Dherange, P. A., Natarajan, B., Trutter, L., Brittain, E. L., Hemnes, A. R., Austin, E. D., Patel, K., Black, S. M., Garcia, J. GN., Yuan, MD PhD, J. X., Vanderpool, R. R., Rischard, F., Makino, A., Bedrick, E. J. & Desai, A., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

2 Scopus citations

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H., Babicheva, A., McDermott, K., Gu, Y., Ayon, R. J., Song, S., Wang, Z., Gupta, A., Zhou, T., Sun, X., Dash, S., Wang, Z., Balistrieri, A., Zheng, Q., Cordery, A. G., Desai, A., Rischard, F., Khalpey, Z. I., Wang, J., Black, S. M. & 3 others, Garcia, J. GN., Makino, A. & Yuan, J., Feb 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

28 Scopus citations

Genome-wide association study in African Americans with acute respiratory distress syndrome identifies the selectin P ligand gene as a risk factor

Bime, C., Pouladi, N., Sammani, S., Batai, K., Casanova, N., Zhou, T., Kempf, C. L., Sun, X., Camp, S. M., Wang, T., Kittles, R. A., Lussier, Y. A., Jones, T. K., Reilly, J. P., Meyer, N. J., Christie, J. D., Karnes, J. H., Gonzalez-Garay, M., Christiani, D. C., Yates, C. R. & 3 others, Wurfel, M. M., Meduri, G. U. & Garcia, J. G. N., Jun 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 11, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18

Gross, C. M., Kellner, M., Wang, T., Lu, Q., Sun, X., Zemskov, E. A., Noonepalle, S., Kangath, A., Kumar, S., Gonzalez-Garay, M., Desai, A., Aggarwal, S., Gorshkov, B., Klinger, C., Verin, A. D., Catravas, J. D., Jacobson, J. R., Yuan, J., Rafikov, R., Garcia, J. GN. & 1 others, Black, S. M., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 614-624 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Wang, T., Brown, M. E., Kelly, G. T., Camp, S. M., Mascarenhas, J. B., Sun, X., Dudek, S. M. & Garcia, J. GN., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

4 Scopus citations

New cases of glucose-6-phosphate dehydrogenase deficiency in pulmonary arterial hypertension

Kurdyukov, S., Eccles, C. A., Desai, A., Gonzalez-Garay, M., Yuan, J., Garcia, J. GN., Rafikova, O. & Rafikov, R., Aug 1 2018, In : PLoS One. 13, 8, e0203493.

Research output: Contribution to journalArticle

4 Scopus citations

Novel mechanism for nicotinamide phosphoribosyltransferase inhibition of TNF-α-mediated apoptosis in human lung endothelial cells

Oita, R. C., Camp, S. M., Ma, W., Ceco, E., Harbeck, M., Singleton, P., Messana, J., Sun, X., Wang, T. & Garcia, J. GN., Jul 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 59, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Tang, H., Wu, K., Wang, J., Vinjamuri, S., Gu, Y., Song, S., Wang, Z., Zhang, Q., Balistrieri, A., Ayon, R. J., Rischard, F., Vanderpool, R., Chen, J., Zhou, G., Desai, A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Makino, A., Dec 1 2018, In : JACC: Basic to Translational Science. 3, 6, p. 744-762 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression

Liu, P., De La Vega, M. R., Sammani, S., Mascarenhas, J. B., Kerins, M., Dodson, M., Sun, X., Wang, T., Ooi, A., Garcia, J. GN. & Zhang, D., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10352-E10361

Research output: Contribution to journalArticle

6 Scopus citations

Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans

Lynn, H., Sun, X., Ayshiev, D., Siegler, J. H., Rizzo, A. N., Karnes, J. H., Garay, M. G., Wang, T., Casanova, N., Camp, S. M., Ellis, N. A. & Garcia, J. G. N., Aug 1 2018, In : PLoS One. 13, 8, e0200916.

Research output: Contribution to journalArticle

2 Scopus citations

The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics

Wang, X., Wang, L., Garcia, J. GN., Dudek, S. M., Shekhawat, G. S. & Dravid, V. P., Dec 1 2018, In : Scientific Reports. 8, 1, 1002.

Research output: Contribution to journalArticle

2 Scopus citations

The splicing factor hnRNPA1 regulates alternate splicing of the MYLK gene

Mascarenhas, J. B., Tchourbanov, A. Y., Danilov, S. M., Zhou, T., Wang, T. & Garcia, J. GN., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 604-613 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

ACE phenotyping in human heart

Tikhomirova, V. E., Kost, O. A., Kryukova, O. V., Golukhova, E. Z., Bulaeva, N. I., Zholbaeva, A. Z., Bokeria, L. A., Garcia, J. GN. & Danilov, S. M., Aug 1 2017, In : PLoS One. 12, 8, e0181976.

Research output: Contribution to journalArticle

8 Scopus citations

An American Thoracic Society/National Heart, Lung, and Blood Institute workshop report: Addressing respiratory Health equality in the United States

Celedón, J. C., Burchard, E. G., Schraufnagel, D., Castillo-Salgado, C., Schenker, M., Balmes, J., Neptune, E., Cummings, K. J., Holguin, F., Riekert, K. A., Wisnivesky, J. P., Garcia, J. G. N., Roman, J., Kittles, R., Ortega, V. E., Redline, S., Mathias, R., Thomas, A., Samet, J. & Ford, J. G., May 1 2017, In : Annals of the American Thoracic Society. 14, 5, p. 814-826 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Association of circulating transcriptomic profiles with mortality in sickle cell disease

Desai, A., Lei, Z., Bahroos, N., Maienschein-Cline, M., Saraf, S. L., Zhang, X., Shah, B. N., Nouraie, S. M., Abbasi, T., Patel, A. R., Lang, R. M., Lussier, Y. A., Garcia, J. GN., Gordeuk, V. R. & Machado, R. F., Jun 1 2017, In : Blood. 129, 22, p. 3009-3016 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

A Transformative Approach to Academic Medicine: The Partnership between the University of Arizona and Banner Health

Cairns, C. B., Bollinger, K. & Garcia, J. GN., Jan 1 2017, In : Academic Medicine. 92, 1, p. 20-22 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH

Song, S., Ayon, R. J., Yamamura, A., Yamamura, H., Dash, S., Babicheva, A., Tang, H., Sun, X., Cordery, A. G., Khalpey, Z. I., Black, S. M., Desai, A., Rischard, F., McDermott, K., Garcia, J. GN., Makino, A. & Yuan, J., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L309-L325

Research output: Contribution to journalArticle

8 Scopus citations

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension

Wu, K., Zhang, Q., Wu, X., Lu, W., Tang, H., Liang, Z., Gu, Y., Song, S., Ayon, R. J., Wang, Z., McDermott, K., Balistrieri, A., Wang, C., Black, S. M., Garcia, J. GN., Makino, A., Yuan, J. & Wang, J., Nov 1 2017, In : British Journal of Pharmacology. 174, 22, p. 4155-4172 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Palumbo, S., Shin, Y. J., Ahmad, K., Desai, A., Quijada, H., Mohamed, M., Knox, A., Sammani, S., Colson, B. A., Wang, T., Garcia, J. G. N. & Hecker, L., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L297-L308

Research output: Contribution to journalArticle

10 Scopus citations

Endothelial cell signaling and ventilator-induced lung injury: Molecular mechanisms, genomic analyses, and therapeutic targets

Wang, T., Gross, C., Desai, A., Zemskov, E., Wu, X., Garcia, A. N., Jacobson, J. R., Yuan, J., Garcia, J. GN. & Black, S. M., Apr 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, p. L452-L476

Research output: Contribution to journalReview article

25 Scopus citations

Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome

Szilágyi, K. L., Liu, C., Zhang, X., Wang, T., Fortman, J. D., Zhang, W. & Garcia, J. GN., Feb 1 2017, In : Translational Research. 180, p. 12-21 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Health disparities in patients with pulmonary arterial hypertension: A blueprint for action: An official American thoracic society statement

Talwar, A., Garcia, J. G. N., Tsai, H., Moreno, M., Lahm, T., Zamanian, R. T., Machado, R., Kawut, S. M., Selej, M., Mathai, S., D'Anna, L. H., Sahni, S., Rodriquez, E. J., Channick, R., Fagan, K., Gray, M., Armstrong, J., Lopez, J. R. & De Jesus Perez, V., Oct 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 8, p. e32-e47

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension

Vanderpool, R. R., Desai, A., Knapp, S. M., Simon, M. A., Abidov, A., Yuan, J., Garcia, J. GN., Hansen, L. M., Knoper, S. R., Naeije, R. & Rischard, F., Aug 1 2017, In : The European respiratory journal. 50, 2

Research output: Contribution to journalLetter

12 Scopus citations

Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J., Catravas, J. D., Rafikov, R., Garcia, J. GN. & 1 others, Black, S. M., Jan 1 2017, In : Free Radical Biology and Medicine. 102, p. 217-228 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
16 Scopus citations

Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium

Wang, X., Bleher, R., Wang, L., Garcia, J. GN., Dudek, S. M., Shekhawat, G. S. & Dravid, V. P., Dec 1 2017, In : Scientific Reports. 7, 1, 14152.

Research output: Contribution to journalArticle

2 Scopus citations

Improved metabolism and redox state with a novel preservation solution: Implications for donor lungs after cardiac death (DCD)

Schipper, D. A., Louis, A. V., Dicken, D. S., Johnson, K., Smolenski, R. T., Black, S. M., Runyan, R. B., Konhilas, J., Garcia, J. GN. & Khalpey, Z. I., 2017, In : Pulmonary Circulation. 7, 2, p. 494-504 11 p.

Research output: Contribution to journalArticle

Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation

Huang, L. S., Jiang, P., Feghali-Bostwick, C., Reddy, S. P., Garcia, J. GN. & Natarajan, V., Nov 1 2017, In : Free Radical Biology and Medicine. 112, p. 162-173 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanical stress and single nucleotide variants regulate alternative splicing of the mylk gene

Mascarenhas, J. B., Tchourbanov, A. Y., Fan, H., Danilov, S. M., Wang, T. & Garcia, J. GN., Jan 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Microbes are associated with host innate immune response in idiopathic pulmonary fibrosis

Huang, Y., Ma, S. F., Espindola, M. S., Vij, R., Oldham, J. M., Huffnagle, G. B., Erb-Downward, J. R., Flaherty, K. R., Moore, B. B., White, E. S., Zhou, T., Li, J., Lussier, Y. A., Han, M. K., Kaminski, N., Garcia, J. GN., Hogaboam, C. M., Martinez, F. J. & Noth, I., Jul 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension

Chen, J., Sysol, J. R., Singla, S., Zhao, S., Yamamura, A., Valdez-Jasso, D., Abbasi, T., Shioura, K. M., Sahni, S., Reddy, V., Sridhar, A., Gao, H., Torres, J., Camp, S. M., Tang, H., Ye, S. Q., Comhair, S., Dweik, R., Hassoun, P., Yuan, J. & 2 others, Garcia, J. GN. & Machado, R. F., Feb 27 2017, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

19 Scopus citations

Particulate matter disrupts human lung endothelial cell barrier integrity via Rho-dependent pathways

Wang, T., Shimizu, Y., Wu, X., Kelly, G. T., Xu, X., Wang, L., Qian, Z., Chen, Y. & Garcia, J. GN., 2017, In : Pulmonary Circulation. 7, 3, p. 617-623 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

Slepian, M. J., Sheriff, J., Hutchinson, M., Tran, P., Bajaj, N., Garcia, J. GN., Saavedra, S. S. & Bluestein, D., Jan 4 2017, In : Journal of Biomechanics. 50, p. 20-25 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Simvastatin-induced sphingosine 1 - Phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells

Sun, X., Mathew, B., Sammani, S., Jacobson, J. R. & Garcia, J. GN., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The ARP 2/3 complex mediates endothelial barrier function and recovery

Belvitch, P., Brown, M. E., Brinley, B. N., Letsiou, E., Rizzo, A. N., Garcia, J. GN. & Dudek, S. M., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

6 Scopus citations