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2019

Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study

Xie, J. Y., Qu, C., Munro, G., Petersen, K. A. & Porreca, F., Aug 1 2019, In : Pain. 160, 8, p. 1847-1855 9 p.

Research output: Contribution to journal › Article

1 Scopus citations

Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache

Kopruszinski, C. M., Navratilova, E., Vagnerova, B., Swiokla, J., Patwardhan, A., Dodick, D. & Porreca, F., Jan 1 2019, (Accepted/In press) In : Cephalalgia.

Research output: Contribution to journal › Article

CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice

Navratilova, E., Rau, J., Oyarzo, J., Tien, J., Mackenzie, K., Stratton, J., Remeniuk, B., Schwedt, T., Anderson, T., Dodick, D. & Porreca, F., Jan 1 2019, (Accepted/In press) In : Cephalalgia.

Research output: Contribution to journal › Article

1 Scopus citations

Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140)

Guerrero, M., Urbano, M., Kim, E. K., Gamo, A. M., Riley, S., Abgaryan, L., Leaf, N., Van Orden, L. J., Brown, S. J., Xie, J. Y., Porreca, F., Cameron, M. D., Rosen, H. & Roberts, E., Feb 28 2019, In : Journal of Medicinal Chemistry. 62, 4, p. 1761-1780 20 p.

Research output: Contribution to journal › Article

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Khanna, R., Patwardhan, A. M., Yang, X., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., Gordon, J., Moutal, A., Vanderah, T. W., Porreca, F. & Ibrahim, M. M., Jan 1 2019, In : Journal of Pain.

Research output: Contribution to journal › Article

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light’ (The Journal of Pain (2019) 20(11) (1293–1306), (S1526590018308149), (10.1016/j.jpain.2019.04.008))

Khanna, R., Patwardhan, A., Yang, X., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., Gordon, J., Moutal, A., Vanderah, T. W., Porreca, F. & Ibrahim, M. M., Dec 2019, In : Journal of Pain. 20, 12, 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

Jassar, H., Nascimento, T. D., Kaciroti, N., DosSantos, M. F., Danciu, T., Koeppe, R. A., Smith, Y. R., Bigal, M. E., Porreca, F., Casey, K. L., Zubieta, J. K. & DaSilva, A. F., Jan 1 2019, In : NeuroImage: Clinical. 23, 101905.

Research output: Contribution to journal › Article

Open Access
4 Scopus citations

Inhibition of experimental visceral pain in rodents by cebranopadol

Schiene, K., Schröder, W., Linz, K., Frosch, S., Tzschentke, T. M., Christoph, T., Xie, J. Y. & Porreca, F., Jun 1 2019, In : Behavioural Pharmacology. 30, 4, p. 320-326 7 p.

Research output: Contribution to journal › Article

2 Scopus citations

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

Navratilova, E., Ji, G., Phelps, C., Qu, C., Hein, M., Yakhnitsa, V., Neugebauer, V. & Porreca, F., Apr 1 2019, In : Pain. 160, 4, p. 824-832 9 p.

Research output: Contribution to journal › Article

8 Scopus citations

Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain

Phelps, C. E., Navratilova, E., Dickenson, A. H., Porreca, F. & Bannister, K., Jul 1 2019, In : Pain. 160, 7, p. 1614-1621 8 p.

Research output: Contribution to journal › Article

2 Scopus citations

Opioid analgesics pass the acid test

Navratilova, E., Patwardhan, A. M. & Porreca, F., Apr 20 2019, In : The Lancet. 393, 10181, p. 1579-1581 3 p.

Research output: Contribution to journal › Comment/debate

Pathophysiology, prevention, and treatment of medication overuse headache

Diener, H. C., Dodick, D., Evers, S., Holle, D., Jensen, R. H., Lipton, R. B., Porreca, F., Silberstein, S. & Schwedt, T., Sep 2019, In : The Lancet Neurology. 18, 9, p. 891-902 12 p.

Research output: Contribution to journal › Review article

5 Scopus citations

Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acid A receptor subtypes for the treatment of chronic pain

Johnstone, T. B. C., Xie, J. Y., Qu, C., Wasiak, D. J., Hogenkamp, D. J., Porreca, F. & Gee, K. W., Jan 1 2019, In : Pain. 160, 1, p. 198-209 12 p.

Research output: Contribution to journal › Article

3 Scopus citations

Post-traumatic headache: epidemiology and pathophysiological insights

Ashina, H., Porreca, F., Anderson, T., Mohammad Amin, F., Ashina, M., Winther Schytz, H. & Dodick, D. W., Oct 1 2019, In : Nature Reviews Neurology. 15, 10, p. 607-617 11 p.

Research output: Contribution to journal › Review article

3 Scopus citations

Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Navratilova, E. & Porreca, F., Feb 6 2019, In : Neuron. 101, 3, p. 353-355 3 p.

Research output: Contribution to journal › Short survey

1 Scopus citations

Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache

Nation, K. M., Dodick, D. W., Navratilova, E. & Porreca, F., Apr 1 2019, In : Cephalalgia. 39, 5, p. 617-625 9 p.

Research output: Contribution to journal › Article

1 Scopus citations

The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Witkin, J. M., Cerne, R., Davis, P. G., Freeman, K. B., do Carmo, J. M., Rowlett, J. K., Methuku, K. R., Okun, A., Gleason, S. D., Li, X., Krambis, M. J., Poe, M., Li, G., Schkeryantz, J. M., Jahan, R., Yang, L., Guo, W., Golani, L. K., Anderson, W. H., Catlow, J. T. & 5 others, Jones, T. M., Porreca, F., Smith, J. L., Knopp, K. L. & Cook, J. M., May 1 2019, In : Pharmacology Biochemistry and Behavior. 180, p. 22-31 10 p.

Research output: Contribution to journal › Article

3 Scopus citations
2018

Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer

Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., Kondo, T., Shinzato, T., Shimizu, T., Fukuchi, Y., Muto, A., Okano, H., Yamanaka, A., Tawfik, V. L., Kuzumaki, N., Navratilova, E., Porreca, F. & Narita, M., Jan 1 2018, In : Molecular Pain. 14

Research output: Contribution to journal › Article

14 Scopus citations

Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats

Cowen, S. L., Phelps, C. E., Navratilova, E., McKinzie, D. L., Okun, A., Husain, O., Gleason, S. D., Witkin, J. M. & Porreca, F., Jul 1 2018, In : Pain. 159, 7, p. 1403-1412 10 p.

Research output: Contribution to journal › Article

2 Scopus citations

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. J. & Lee, Y. S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journal › Article

1 Scopus citations

Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain

Remeniuk, B., King, T., Sukhtankar, D., Nippert, A., Li, N., Li, F., Cheng, K., Rice, K. C. & Porreca, F., Apr 1 2018, In : Pain. 159, 4, p. 684-698 15 p.

Research output: Contribution to journal › Article

10 Scopus citations

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., Jan 1 2018, In : Molecular Pain. 14

Research output: Contribution to journal › Article

7 Scopus citations

In Reply

Garami, A., Ibrahim, M., Gilbraith, K., Khanna, R., Pakai, E., Miko, A., Pinter, E., Romanovsky, A. A., Porreca, F. & Patwardhan, A. M., Aug 1 2018, In : Anesthesiology. 129, 2, p. 378-379 2 p.

Research output: Contribution to journal › Comment/debate

Kappa Opioid Receptor Distribution and Function in Primary Afferents

Snyder, L. M., Chiang, M. C., Loeza-Alcocer, E., Omori, Y., Hachisuka, J., Sheahan, T. D., Gale, J. R., Adelman, P. C., Sypek, E. I., Fulton, S. A., Friedman, R. L., Wright, M. C., Duque, M. G., Lee, Y. S., Hu, Z., Huang, H., Cai, X., Meerschaert, K. A., Nagarajan, V., Hirai, T. & 7 others, Scherrer, G., Kaplan, D. H., Porreca, F., Davis, B. M., Gold, M. S., Koerber, H. R. & Ross, S. E., Sep 19 2018, In : Neuron. 99, 6, p. 1274-1288.e6

Research output: Contribution to journal › Article

11 Scopus citations

Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain

Nation, K. M., De Felice, M., Hernandez, P. I., Dodick, D. W., Neugebauer, V., Navratilova, E. & Porreca, F., May 1 2018, In : Pain. 159, 5, p. 919-928 10 p.

Research output: Contribution to journal › Article

16 Scopus citations

Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain

Gomtsian, L., Bannister, K., Eyde, N., Robles, D., Dickenson, A. H., Porreca, F. & Navratilova, E., Dec 1 2018, In : Pain. 159, 12, p. 2512-2521 10 p.

Research output: Contribution to journal › Article

5 Scopus citations

Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia

Godfrey, L., Iannitelli, A., Garrett, N. L., Moger, J., Imbert, I., King, T., Porreca, F., Soundararajan, R., Lalatsa, A., Schätzlein, A. G. & Uchegbu, I. F., Jan 28 2018, In : Journal of Controlled Release. 270, p. 135-144 10 p.

Research output: Contribution to journal › Article

9 Scopus citations

Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone

Patel, R., Qu, C., Xie, J. Y., Porreca, F. & Dickenson, A. H., Sep 1 2018, In : Pain. 159, 9, p. 1887-1899 13 p.

Research output: Contribution to journal › Article

9 Scopus citations

The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced L-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia

Flores, A. J., Bartlett, M. J., Root, B. K., Parent, K. L., Heien, M. L., Porreca, F., Polt, R. L., Sherman, S. J. & Falk, T., Oct 1 2018, In : Neuropharmacology. 141, p. 260-271 12 p.

Research output: Contribution to journal › Article

3 Scopus citations

The opioid crisis and … reconsidering the use of drugs that affect body temperature

Patwardhan, A., Porreca, F., Schmidt, W. K. & Romanovsky, A. A., Jan 2 2018, In : Temperature. 5, 1, p. 1-3 3 p.

Research output: Contribution to journal › Editorial

Open Access
1 Scopus citations
2017

Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla

Hitomi, S., Kross, K., Kurose, M., Porreca, F. & Meng, I. D., Apr 1 2017, In : Cephalalgia. 37, 5, p. 407-417 11 p.

Research output: Contribution to journal › Article

7 Scopus citations

Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine

Rice, F. L., Xie, J. Y., Albrecht, P. J., Acker, E., Bourgeois, J., Navratilova, E., Dodick, D. W. & Porreca, F., Dec 1 2017, In : Cephalalgia. 37, 14, p. 1350-1372 23 p.

Research output: Contribution to journal › Article

11 Scopus citations

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Moutal, A., Yang, X., Li, W., Gilbraith, K. B., Luo, S., Cai, S., François-Moutal, L., Chew, L. A., Yeon, S. K., Bellampalli, S. S., Qu, C., Xie, J. Y., Ibrahim, M. M., Khanna, M., Park, K. D., Porreca, F. & Khanna, R., Jan 1 2017, In : Pain. 158, 12, p. 2301-2319 19 p.

Research output: Contribution to journal › Article

23 Scopus citations

Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., Lavigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., Navratilova, E., Dodick, D., Rosen, H., Roberts, E. & Porreca, F., Jul 1 2017, In : Cephalalgia. 37, 8, p. 780-794 15 p.

Research output: Contribution to journal › Article

27 Scopus citations

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats

Ibrahim, M. M., Patwardhan, A. M., Gilbraith, K. B., Moutal, A., Yang, X., Chew, L. A., Largent-Milnes, T., Malan, T. P., Vanderah, T. W., Porreca, F. & Khanna, R., Feb 1 2017, In : Pain. 158, 2, p. 347-360 14 p.

Research output: Contribution to journal › Article

19 Scopus citations

Mechanisms of craniofacial pain

Chichorro, J. G., Porreca, F. & Sessle, B., Jun 1 2017, In : Cephalalgia. 37, 7, p. 613-626 14 p.

Research output: Contribution to journal › Review article

18 Scopus citations

Mediation of movement-induced breakthrough cancer pain by IB4-binding nociceptors in rats

Havelin, J., Imbert, I., Sukhtankar, D., Remeniuk, B., Pelletier, I., Gentry, J., Okun, A., Tiutan, T., Porreca, F. & King, T. E., May 17 2017, In : Journal of Neuroscience. 37, 20, p. 5111-5122 12 p.

Research output: Contribution to journal › Article

7 Scopus citations

Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

Bannister, K., Qu, C., Navratilova, E., Oyarzo, J., Xie, J. Y., King, T., Dickenson, A. H. & Porreca, F., Jan 1 2017, In : Pain. 158, 12, p. 2386-2395 10 p.

Research output: Contribution to journal › Article

22 Scopus citations

Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

Kopruszinski, C. M., Xie, J. Y., Eyde, N. M., Remeniuk, B., Walter, S., Stratton, J., Bigal, M., Chichorro, J. G., Dodick, D. & Porreca, F., May 1 2017, In : Cephalalgia. 37, 6, p. 560-570 11 p.

Research output: Contribution to journal › Article

24 Scopus citations

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Remesic, M., Hruby, V. J., Porreca, F. & Lee, Y. S., Jun 21 2017, In : ACS Chemical Neuroscience. 8, 6, p. 1147-1158 12 p.

Research output: Contribution to journal › Review article

11 Scopus citations

Reward, motivation, and emotion of pain and its relief

Porreca, F. & Navratilova, E., Jan 1 2017, In : Pain. 158, 4, p. S43-S49

Research output: Contribution to journal › Article

27 Scopus citations

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

Garami, A., Ibrahim, M., Gilbraith, K., Khanna, R., Pakai, E., Miko, A., Pinter, E., Romanovsky, A. A., Porreca, F. & Patwardhan, A. M., Nov 1 2017, In : Anesthesiology. 127, 5, p. 813-823 11 p.

Research output: Contribution to journal › Article

10 Scopus citations
2016

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

Moutal, A., Chew, L. A., Yang, X., Wang, Y., Yeon, S. K., Telemi, E., Meroueh, S., Park, K. D., Shrinivasan, R., Gilbraith, K. B., Qu, C., Xie, J. Y., Patwardhan, A. M., Vanderah, T. W., Khanna, M., Porreca, F. & Khanna, R., Jul 1 2016, In : Pain. 157, 7, p. 1448-1463 16 p.

Research output: Contribution to journal › Article

24 Scopus citations

Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis

Havelin, J., Imbert, I., Cormier, J., Allen, J., Porreca, F. & King, T., Mar 1 2016, In : Journal of Pain. 17, 3, p. 374-382 9 p.

Research output: Contribution to journal › Article

38 Scopus citations

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors

Lee, Y. S., Remesic, M., Ramos-Colon, C., Hall, S. M., Kuzmin, A., Rankin, D., Porreca, F., Lai, J. & Hruby, V. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5513-5516 4 p.

Research output: Contribution to journal › Article

3 Scopus citations

Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain

Hall, S. M., LeBaron, L., Ramos-Colon, C., Qu, C., Xie, J. Y., Porreca, F., Lai, J., Lee, Y. S. & Hruby, V. J., Dec 21 2016, In : ACS Chemical Neuroscience. 7, 12, p. 1746-1752 7 p.

Research output: Contribution to journal › Article

5 Scopus citations

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

Andrews, N. A., Latrémolière, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., MacHin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 1 2016, In : Pain. 157, 4, p. 901-909 9 p.

Research output: Contribution to journal › Article

28 Scopus citations

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain

Okun, A., McKinzie, D. L., Witkin, J. M., Remeniuk, B., Husein, O., Gleason, S. D., Oyarzo, J., Navratilova, E., McElroy, B., Cowen, S. L., Kennedy, J. D. & Porreca, F., Aug 10 2016, In : Pain. 157, 12, p. 2731-2738 8 p.

Research output: Contribution to journal › Article

15 Scopus citations

Opioid Analgesics and Antagonists

Raffa, R. B., Ossipov, M. H. & Porreca, F., Sep 27 2016, Pharmacology and Therapeutics for Dentistry: Seventh Edition. Elsevier, p. 241-256 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Positive emotions and brain reward circuits in chronic pain

Navratilova, E., Morimura, K., Xie, J. Y., Atcherley, C. W., Ossipov, M. H. & Porreca, F., Jun 1 2016, In : Journal of Comparative Neurology. 524, 8, p. 1646-1652 7 p.

Research output: Contribution to journal › Article

32 Scopus citations