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• 2020

  Amygdala, neuropeptides, and chronic pain-related affective behaviors

  Neugebauer, V., Mazzitelli, M., Cragg, B., Ji, G., Navratilova, E. & Porreca, F., Jun 15 2020, In: Neuropharmacology. 170, 108052.

  Research output: Contribution to journal › Review article › peer-review

  • Neuropeptides
  • Amygdala
  • Chronic Pain
  • Pain
  • Corticotropin-Releasing Hormone
  2 Scopus citations

• An Emerging Role for Prolactin in Female-Selective Pain

  Chen, Y., Navratilova, E., Dodick, D. W. & Porreca, F., Aug 2020, In: Trends in Neurosciences. 43, 8, p. 635-648 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prolactin
  • Prolactin Receptors
  • Pain
  • Nociceptors
  • Sex Characteristics
  1 Scopus citations

• A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain

  Kopruszinski, C. M., Navratilova, E., Swiokla, J., Dodick, D. W., Chessell, I. P. & Porreca, F., 2020, (Accepted/In press) In: Cephalalgia.

  Research output: Contribution to journal › Article › peer-review

  • (1R,5S)-4-methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one
  • Calcitonin Gene-Related Peptide Receptors
  • Migraine Disorders
  • Hyperalgesia
  • Rodentia

• A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens

  Gee, T. A., Weintraub, N. C., Lu, D., Phelps, C. E., Navratilova, E., Heien, M. L. & Porreca, F., Oct 1 2020, In: Pain. 161, 10, p. 2376-2384 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleus Accumbens
  • Dopamine
  • Pain
  • Capsaicin
  • Synaptic Transmission

• Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine

  Kopruszinski, C. M., Thornton, P., Arnold, J., Newton, P., Lowne, D., Navratilova, E., Swiokla, J., Dodick, D. W., Dobson, C., Gurrell, I., Chessell, I. P. & Porreca, F., Dec 2020, In: Cephalalgia. 40, 14, p. 1535-1550 16 p.

  Research output: Contribution to journal › Article › peer-review

  • PAR-2 Receptor
  • Hyperalgesia
  • Migraine Disorders
  • Calcitonin Gene-Related Peptide
  • Monoclonal Antibodies

• Chronicling changes in the somatosensory neurons after peripheral nerve injury

  Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F. & Olivera, B. M., Oct 20 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 42, p. 26414-26421 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Peripheral Nerve Injuries
  • Spinal Nerves
  • Neurons
  • Ligation
  • Bradykinin

• Erratum: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females (Science Translational Medicine DOI: 10.1126/scitranslmed.aay7550)

  Chen, Y., Moutal, A., Navratilova, E., Kopruszinski, C., Yue, X., Ikegami, M., Chow, M., Kanazawa, I., Bellampalli, S. S., Xie, J., Patwardhan, A., Rice, K., Fields, H., Akopian, A., Neugebauer, V., Dodick, D., Khanna, R. & Porreca, F., Mar 4 2020, In: Science translational medicine. 12, 533, eabb4549.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Prolactin Receptors
  • Nociceptors
  • Translational Medical Research
  • Hyperalgesia
  • Opioid Analgesics

• Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial

  Martin, L. F., Patwardhan, A. M., Jain, S. V., Salloum, M. M., Freeman, J., Khanna, R., Gannala, P., Goel, V., Jones-MacFarland, F. N., Killgore, W. D. S., Porreca, F. & Ibrahim, M. M., 2020, (Accepted/In press) In: Cephalalgia.

  Research output: Contribution to journal › Article › peer-review

  • Methyl Green
  • Migraine Disorders
  • Cross-Over Studies
  • Headache
  • Clinical Trials

• Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache

  Rau, J. C., Navratilova, E., Oyarzo, J., Johnson, K. W., Aurora, S. K., Schwedt, T. J., Dodick, D. W. & Porreca, F., Aug 1 2020, In: Cephalalgia. 40, 9, p. 903-912 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2,4,6-trifluoro-N-(6-((1-methylpiperidin-4-yl)carbonyl)pyridin-2yl)benzamide
  • Secondary Headache Disorders
  • Sumatriptan
  • Hyperalgesia
  • Migraine Disorders
  1 Scopus citations

• Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents

  Kopruszinski, C. M., Swiokla, J., Lee, Y. S., Navratilova, E., VanderVeen, L., Yang, M., Liu, Y., Miyazaki, T., Schmidt, W. K., Zalevsky, J. & Porreca, F., 2020, (Accepted/In press) In: Cellular and Molecular Neurobiology.

  Research output: Contribution to journal › Article › peer-review

  • NKTR-181
  • Analgesics
  • Rodentia
  • Morphine
  • Pharmacology
  1 Scopus citations

• Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex

  Navratilova, E., Nation, K., Remeniuk, B., Neugebauer, V., Bannister, K., Dickenson, A. H. & Porreca, F., Mar 1 2020, In: Pain. 161, 3, p. 609-618 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Central Amygdaloid Nucleus
  • Gyrus Cinguli
  • Neuralgia
  • Morphine
  • Opioid Analgesics
  3 Scopus citations

• Supraspinal opioid circuits differentially modulate spinal neuronal responses in neuropathic rats

  Dickenson, A. H., Navratilova, E., Patel, R., Porreca, F. & Bannister, K., 2020, (Accepted/In press) In: Anesthesiology. p. 881-894 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Morphine
  • Opioid Analgesics
  • Gyrus Cinguli
  • Central Amygdaloid Nucleus
  • Brain Stem
  4 Scopus citations

• The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

  Chen, Y., Moutal, A., Navratilova, E., Kopruszinski, C., Yue, X., Ikegami, M., Chow, M., Kanazawa, I., Bellampalli, S. S., Xie, J., Patwardhan, A., Rice, K., Fields, H., Akopian, A., Neugebauer, V., Dodick, D., Khanna, R. & Porreca, F., Feb 5 2020, In: Science translational medicine. 12, 529, eaay7550.

  Research output: Contribution to journal › Article › peer-review

  • Prolactin Receptors
  • Nociceptors
  • Hyperalgesia
  • Opioid Analgesics
  • Prolactin
  4 Scopus citations

• Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache

  Navratilova, E., Behravesh, S., Oyarzo, J., Dodick, D. W., Banerjee, P. & Porreca, F., Aug 1 2020, In: Cephalalgia. 40, 9, p. 892-902 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ubrogepant
  • Secondary Headache Disorders
  • Hyperalgesia
  • Sumatriptan
  • Skin
  2 Scopus citations

• Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds

  Christensen, S. L., Hansen, R. B., Storm, M. A., Olesen, J., Hansen, T. F., Ossipov, M., Izarzugaza, J. M. G., Porreca, F. & Kristensen, D. M., Apr 1 2020, In: European Journal of Pain (United Kingdom). 24, 4, p. 783-790 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Central Nervous System Sensitization
  • Pain
  • Hyperalgesia
  • Touch
  • Uncertainty
  5 Scopus citations
• 2019

  Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study

  Xie, J. Y., Qu, C., Munro, G., Petersen, K. A. & Porreca, F., Aug 1 2019, In: Pain. 160, 8, p. 1847-1855 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Constriction
  • Hyperalgesia
  • Wounds and Injuries
  • Neuralgia
  • Gabapentin
  2 Scopus citations

• Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache

  Kopruszinski, C. M., Navratilova, E., Vagnerova, B., Swiokla, J., Patwardhan, A., Dodick, D. & Porreca, F., Jan 1 2019, (Accepted/In press) In: Cephalalgia.

  Research output: Contribution to journal › Article › peer-review

  • Secondary Headache Disorders
  • Dronabinol
  • Cannabinoids
  • Sensory Thresholds
  • Cannabinoid Receptor Agonists
  1 Scopus citations

• CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice

  Navratilova, E., Rau, J., Oyarzo, J., Tien, J., Mackenzie, K., Stratton, J., Remeniuk, B., Schwedt, T., Anderson, T., Dodick, D. & Porreca, F., Dec 1 2019, In: Cephalalgia. 39, 14, p. 1762-1775 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Hyperalgesia
  • Calcitonin Gene-Related Peptide
  • Skin
  • Light
  20 Scopus citations

• Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140)

  Guerrero, M., Urbano, M., Kim, E. K., Gamo, A. M., Riley, S., Abgaryan, L., Leaf, N., Van Orden, L. J., Brown, S. J., Xie, J. Y., Porreca, F., Cameron, M. D., Rosen, H. & Roberts, E., Feb 28 2019, In: Journal of Medicinal Chemistry. 62, 4, p. 1761-1780 20 p.

  Research output: Contribution to journal › Article › peer-review

  • kappa Opioid Receptor
  • Narcotic Antagonists
  • Pyrans
  • Pharmaceutical Chemistry
  • Dynorphins
  6 Scopus citations

• Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

  Khanna, R., Patwardhan, A., Yang, X., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., Gordon, J., Moutal, A., Vanderah, T. W., Porreca, F. & Ibrahim, M. M., Nov 2019, In: Journal of Pain. 20, 11, p. 1293-1306 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperalgesia
  • Light
  • Pain
  • Wounds and Injuries
  • Color
  2 Scopus citations

• Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light’ (The Journal of Pain (2019) 20(11) (1293–1306), (S1526590018308149), (10.1016/j.jpain.2019.04.008))

  Khanna, R., Patwardhan, A., Yang, X., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., Gordon, J., Moutal, A., Vanderah, T. W., Porreca, F. & Ibrahim, M. M., Dec 2019, In: Journal of Pain. 20, 12, p. 1509 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Emotions
  • Light
  • Pain
  • Wounds and Injuries

• Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

  Jassar, H., Nascimento, T. D., Kaciroti, N., DosSantos, M. F., Danciu, T., Koeppe, R. A., Smith, Y. R., Bigal, M. E., Porreca, F., Casey, K. L., Zubieta, J. K. & DaSilva, A. F., 2019, In: NeuroImage: Clinical. 23, 101905.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Limbic System
  • Migraine Disorders
  • Synaptic Transmission
  • Opioid Analgesics
  • Opioid Receptors
  8 Scopus citations

• Inhibition of experimental visceral pain in rodents by cebranopadol

  Schiene, K., Schröder, W., Linz, K., Frosch, S., Tzschentke, T. M., Christoph, T., Xie, J. Y. & Porreca, F., Jun 1 2019, In: Behavioural Pharmacology. 30, 4, p. 320-326 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'H)-pyrano(3,4-b)indol)-4-amine
  • Visceral Pain
  • Rodentia
  • Hyperalgesia
  • Inhibition (Psychology)
  2 Scopus citations

• Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

  Navratilova, E., Ji, G., Phelps, C., Qu, C., Hein, M., Yakhnitsa, V., Neugebauer, V. & Porreca, F., 2019, In: Pain. 160, 4, p. 824-832 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Central Amygdaloid Nucleus
  • kappa Opioid Receptor
  • norbinaltorphimine
  • Neuralgia
  • Spinal Nerves
  20 Scopus citations

• Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain

  Phelps, C. E., Navratilova, E., Dickenson, A. H., Porreca, F. & Bannister, K., Jul 1 2019, In: Pain. 160, 7, p. 1614-1621 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffuse Noxious Inhibitory Control
  • Central Amygdaloid Nucleus
  • Neuralgia
  • Opioid Analgesics
  • Spinal Nerves
  8 Scopus citations

• Opioid analgesics pass the acid test

  Navratilova, E., Patwardhan, A. M. & Porreca, F., Apr 20 2019, In: The Lancet. 393, 10181, p. 1579-1581 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Pathophysiology, prevention, and treatment of medication overuse headache

  Diener, H. C., Dodick, D., Evers, S., Holle, D., Jensen, R. H., Lipton, R. B., Porreca, F., Silberstein, S. & Schwedt, T., Sep 2019, In: The Lancet Neurology. 18, 9, p. 891-902 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Secondary Headache Disorders
  • Headache
  • Headache Disorders
  • Patient Education
  • Chronic Pain
  27 Scopus citations

• Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acid^A receptor subtypes for the treatment of chronic pain

  Johnstone, T. B. C., Xie, J. Y., Qu, C., Wasiak, D. J., Hogenkamp, D. J., Porreca, F. & Gee, K. W., Jan 1 2019, In: Pain. 160, 1, p. 198-209 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Nerves
  • Neuralgia
  • Chronic Pain
  • Ligation
  • Hyperalgesia
  5 Scopus citations

• Post-traumatic headache: epidemiology and pathophysiological insights

  Ashina, H., Porreca, F., Anderson, T., Mohammad Amin, F., Ashina, M., Winther Schytz, H. & Dodick, D. W., Oct 1 2019, In: Nature Reviews Neurology. 15, 10, p. 607-617 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Epidemiology
  • Primary Headache Disorders
  • Secondary Headache Disorders
  • Tension-Type Headache
  • Brain Concussion
  24 Scopus citations

• Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

  Navratilova, E. & Porreca, F., Feb 6 2019, In: Neuron. 101, 3, p. 353-355 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Neurokinin-1 Receptors
  • Substance P
  • Neuropeptides
  • Mast Cells
  • Immune System
  5 Scopus citations

• Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache

  Nation, K. M., Dodick, D. W., Navratilova, E. & Porreca, F., Apr 1 2019, In: Cephalalgia. 39, 5, p. 617-625 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffuse Noxious Inhibitory Control
  • Secondary Headache Disorders
  • Migraine Disorders
  • Sumatriptan
  • Pain
  6 Scopus citations

• The α2,3-selective potentiator of GABA _A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

  Witkin, J. M., Cerne, R., Davis, P. G., Freeman, K. B., do Carmo, J. M., Rowlett, J. K., Methuku, K. R., Okun, A., Gleason, S. D., Li, X., Krambis, M. J., Poe, M., Li, G., Schkeryantz, J. M., Jahan, R., Yang, L., Guo, W., Golani, L. K., Anderson, W. H., Catlow, J. T. & 5 others, Jones, T. M., Porreca, F., Smith, J. L., Knopp, K. L. & Cook, J. M., May 2019, In: Pharmacology Biochemistry and Behavior. 180, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review

  • KRM-II-81
  • Spinal Nerves
  • Rats
  • GABA-A Receptors
  • Formaldehyde
  9 Scopus citations
• 2018

  Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer

  Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., Kondo, T., Shinzato, T., Shimizu, T., Fukuchi, Y., Muto, A., Okano, H., Yamanaka, A., Tawfik, V. L., Kuzumaki, N., Navratilova, E., Porreca, F. & Narita, M., Jan 1 2018, In: Molecular Pain. 14

  Research output: Contribution to journal › Article › peer-review

  • Bone Neoplasms
  • Ventral Tegmental Area
  • Hyperalgesia
  • Dopaminergic Neurons
  • Nucleus Accumbens
  21 Scopus citations

• Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats

  Cowen, S. L., Phelps, C. E., Navratilova, E., McKinzie, D. L., Okun, A., Husain, O., Gleason, S. D., Witkin, J. M. & Porreca, F., Jul 1 2018, In: Pain. 159, 7, p. 1403-1412 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Nerves
  • Chronic Pain
  • Ligation
  • Learning
  • Animals
  5 Scopus citations

• Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

  Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. & Lee, Y. S., Jul 23 2018, In: Bioorganic and Medicinal Chemistry. 26, 12, p. 3664-3667 4 p.

  Research output: Contribution to journal › Article › peer-review

  • biphalin
  • kappa Opioid Receptor
  • delta Opioid Receptor
  • mu Opioid Receptor
  • Opioid Receptors
  3 Scopus citations

• Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain

  Remeniuk, B., King, T., Sukhtankar, D., Nippert, A., Li, N., Li, F., Cheng, K., Rice, K. C. & Porreca, F., Apr 1 2018, In: Pain. 159, 4, p. 684-698 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Neoplasms
  • 20,21-epoxyresibufogenin-3-formate
  • Cancer Pain
  • Interleukin-6
  • Bone Remodeling
  14 Scopus citations

• Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

  Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., Jan 1 2018, In: Molecular Pain. 14

  Research output: Contribution to journal › Article › peer-review

  • isospaglumic acid
  • Microdialysis
  • Nucleus Accumbens
  • Mass Spectrometry
  • Pain
  9 Scopus citations

• In Reply

  Garami, A., Ibrahim, M., Gilbraith, K., Khanna, R., Pakai, E., Miko, A., Pinter, E., Romanovsky, A. A., Porreca, F. & Patwardhan, A. M., Aug 1 2018, In: Anesthesiology. 129, 2, p. 378-379 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Kappa Opioid Receptor Distribution and Function in Primary Afferents

  Snyder, L. M., Chiang, M. C., Loeza-Alcocer, E., Omori, Y., Hachisuka, J., Sheahan, T. D., Gale, J. R., Adelman, P. C., Sypek, E. I., Fulton, S. A., Friedman, R. L., Wright, M. C., Duque, M. G., Lee, Y. S., Hu, Z., Huang, H., Cai, X., Meerschaert, K. A., Nagarajan, V., Hirai, T. & 7 others, Scherrer, G., Kaplan, D. H., Porreca, F., Davis, B. M., Gold, M. S., Koerber, H. R. & Ross, S. E., Sep 19 2018, In: Neuron. 99, 6, p. 1274-1288.e6

  Research output: Contribution to journal › Article › peer-review

  • kappa Opioid Receptor
  • Spinal Cord Dorsal Horn
  • Sensory Receptor Cells
  • Neurogenic Inflammation
  • Mechanoreceptors
  23 Scopus citations

• Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain

  Nation, K. M., De Felice, M., Hernandez, P. I., Dodick, D. W., Neugebauer, V., Navratilova, E. & Porreca, F., May 1 2018, In: Pain. 159, 5, p. 919-928 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffuse Noxious Inhibitory Control
  • Central Amygdaloid Nucleus
  • kappa Opioid Receptor
  • Pain
  • Morphine
  27 Scopus citations

• Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain

  Gomtsian, L., Bannister, K., Eyde, N., Robles, D., Dickenson, A. H., Porreca, F. & Navratilova, E., 2018, In: Pain. 159, 12, p. 2512-2521 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Pain
  • Gyrus Cinguli
  • Morphine
  • Chronic Pain
  • Rodentia
  12 Scopus citations

• Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia

  Godfrey, L., Iannitelli, A., Garrett, N. L., Moger, J., Imbert, I., King, T., Porreca, F., Soundararajan, R., Lalatsa, A., Schätzlein, A. G. & Uchegbu, I. F., Jan 28 2018, In: Journal of Controlled Release. 270, p. 135-144 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Enkephalins
  • Analgesia
  • Nanoparticles
  • Peptides
  • Brain
  20 Scopus citations

• Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone

  Patel, R., Qu, C., Xie, J. Y., Porreca, F. & Dickenson, A. H., Sep 1 2018, In: Pain. 159, 9, p. 1887-1899 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Nerves
  • atipamezole
  • Thalamus
  • Reboxetine
  • Adrenergic Neurons
  10 Scopus citations

• The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced L-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia

  Flores, A. J., Bartlett, M. J., Root, B. K., Parent, K. L., Heien, M. L., Porreca, F., Polt, R., Sherman, S. J. & Falk, T., Oct 2018, In: Neuropharmacology. 141, p. 260-271 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycopeptides
  • Dopamine Receptors
  • Dyskinesias
  • N-Methyl-D-Aspartate Receptors
  • Opioid Analgesics
  7 Scopus citations

• The opioid crisis and … reconsidering the use of drugs that affect body temperature

  Patwardhan, A., Porreca, F., Schmidt, W. K. & Romanovsky, A. A., Jan 2 2018, In: Temperature. 5, 1, p. 1-3 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  1 Scopus citations
• 2017

  Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla

  Hitomi, S., Kross, K., Kurose, M., Porreca, F. & Meng, I. D., Apr 1 2017, In: Cephalalgia. 37, 5, p. 407-417 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-fos
  • Morphine
  • N-methylnaloxone
  • Neurons
  • Headache
  8 Scopus citations

• Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine

  Rice, F. L., Xie, J. Y., Albrecht, P. J., Acker, E., Bourgeois, J., Navratilova, E., Dodick, D. W. & Porreca, F., Dec 1 2017, In: Cephalalgia. 37, 14, p. 1350-1372 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Unmyelinated Nerve Fibers
  • Macaca mulatta
  • Migraine Disorders
  • Adrenergic Receptors
  • Anatomy
  15 Scopus citations

• CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

  Moutal, A., Yang, X., Li, W., Gilbraith, K. B., Luo, S., Cai, S., François-Moutal, L., Chew, L. A., Yeon, S. K., Bellampalli, S. S., Qu, C., Xie, J. Y., Ibrahim, M. M., Khanna, M., Park, K. D., Porreca, F. & Khanna, R., 2017, In: Pain. 158, 12, p. 2301-2319 19 p.

  Research output: Contribution to journal › Article › peer-review

  • collapsin response mediator protein-2
  • Lacosamide
  • Neurofibromatosis 1 Genes
  • Neurofibromatosis 1
  • Clustered Regularly Interspaced Short Palindromic Repeats
  33 Scopus citations

• Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

  Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., Lavigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., Navratilova, E., Dodick, D., Rosen, H., Roberts, E. & Porreca, F., Jul 1 2017, In: Cephalalgia. 37, 8, p. 780-794 15 p.

  Research output: Contribution to journal › Article › peer-review

  • kappa Opioid Receptor
  • Narcotic Antagonists
  • Migraine Disorders
  • Hyperalgesia
  • Central Amygdaloid Nucleus
  36 Scopus citations

• Long-lasting antinociceptive effects of green light in acute and chronic pain in rats

  Ibrahim, M. M., Patwardhan, A., Gilbraith, K. B., Moutal, A., Yang, X., Chew, L. A., Largent-Milnes, T., Malan, T. P., Vanderah, T. W., Porreca, F. & Khanna, R., Feb 1 2017, In: Pain. 158, 2, p. 347-360 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Methyl Green
  • Acute Pain
  • Chronic Pain
  • Light
  • Contact Lenses
  25 Scopus citations