A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M.M. Valente, A. A.Leslie Gunatilaka, David G.I. Kingston, Maria L. Patitucci, Angelo C. Pinto

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalJournal Of Natural Products
Volume60
Issue number5
DOIs
StatePublished - Jun 9 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Valente, L. M. M., Gunatilaka, A. A. L., Kingston, D. G. I., Patitucci, M. L., & Pinto, A. C. (1997). A bioactive seco-rosane diterpenoid from Vellozia candida. Journal Of Natural Products, 60(5), 478-481. https://doi.org/10.1021/np960695a