A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M M Valente, Leslie Gunatilaka, David G I Kingston, Maria L. Patitucci, Angelo C. Pinto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalJournal of Natural Products
Volume60
Issue number5
DOIs
StatePublished - 1997

Fingerprint

Vellozia
Diterpenes
Candida
diterpenoids
DNA Repair-Deficiency Disorders
Bioassay
alcohol abuse
Fractionation
DNA repair
Biological Assay
Yeast
Toxicity
Saccharomyces cerevisiae
fractionation
Repair
bioassays
toxicity
mutants
DNA
extracts

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Valente, L. M. M., Gunatilaka, L., Kingston, D. G. I., Patitucci, M. L., & Pinto, A. C. (1997). A bioactive seco-rosane diterpenoid from Vellozia candida. Journal of Natural Products, 60(5), 478-481. https://doi.org/10.1021/np960695a

A bioactive seco-rosane diterpenoid from Vellozia candida. / Valente, Ligia M M; Gunatilaka, Leslie; Kingston, David G I; Patitucci, Maria L.; Pinto, Angelo C.

In: Journal of Natural Products, Vol. 60, No. 5, 1997, p. 478-481.

Research output: Contribution to journalArticle

Valente, LMM, Gunatilaka, L, Kingston, DGI, Patitucci, ML & Pinto, AC 1997, 'A bioactive seco-rosane diterpenoid from Vellozia candida', Journal of Natural Products, vol. 60, no. 5, pp. 478-481. https://doi.org/10.1021/np960695a
Valente, Ligia M M ; Gunatilaka, Leslie ; Kingston, David G I ; Patitucci, Maria L. ; Pinto, Angelo C. / A bioactive seco-rosane diterpenoid from Vellozia candida. In: Journal of Natural Products. 1997 ; Vol. 60, No. 5. pp. 478-481.
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