TY - GEN
T1 - A biophysical model of cortical up and down states
T2 - 12th International Summer School on Neural Networks
AU - Navratilova, Zaneta
AU - Fellous, Jean Marc
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - During slow-wave sleep, cortical neurons oscillate between up and down states. Using a computational model of cortical neurons with realistic synaptic transmission, we determined that reverberation of activity in a small network of about 40 pyramidal cells could account for the properties of up states in vivo. We found that experimentally accessible quantities such as membrane potential fluctuations, firing rates and up state durations could be used as indicators of the size of the network undergoing the up state. We also show that the H-current, together with feed-forward inhibition can act as a gating mechanism for up state initiation.
AB - During slow-wave sleep, cortical neurons oscillate between up and down states. Using a computational model of cortical neurons with realistic synaptic transmission, we determined that reverberation of activity in a small network of about 40 pyramidal cells could account for the properties of up states in vivo. We found that experimentally accessible quantities such as membrane potential fluctuations, firing rates and up state durations could be used as indicators of the size of the network undergoing the up state. We also show that the H-current, together with feed-forward inhibition can act as a gating mechanism for up state initiation.
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U2 - 10.1007/978-3-540-88853-6_5
DO - 10.1007/978-3-540-88853-6_5
M3 - Conference contribution
AN - SCOPUS:56749154314
SN - 3540888527
SN - 9783540888529
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 61
EP - 66
BT - Dynamic Brain - from Neural Spikes to Behaviors - 12th International Summer School on Neural Networks, Revised Lectures
PB - Springer-Verlag
Y2 - 5 December 2007 through 12 December 2007
ER -