A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species

Michael G. Espey, Katrina M. Miranda, Douglas D. Thomas, Sandhya Xavier, Deborah Citrin, Michael P. Vitek, David A. Wink

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Nitric oxide (nitrogen monoxide, NO) plays a veritable cornucopia of regulatory roles in normal physiology. In contrast, NO has also been implicated in the etiology and sequela of numerous neurodegenerative diseases that involve reactive oxygen species (ROS) and nitrogen oxide species (RNOS). In this setting, NO is often viewed solely as pathogenic; however, the chemistry of NO can also be a significant factor in lessening injury mediated by both ROS and RNOS. The relationship between NO and oxidation, nitrosation, and nitration reactions is summarized. The salient factors that determine whether NO promotes, abates, or interconnects these chemistries are emphasized. From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted.

Original languageEnglish (US)
Pages (from-to)195-206
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume962
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Nitration
  • Nitrite
  • Nitrosative stress
  • Oxidative stress
  • Peroxidase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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