A clinical and histopathological study of François-Neetens speckled corneal dystrophy

Don H. Nicholson, W. Richard Green, Harold E. Cross, Kenneth R. Kenyon, Darcy Massof

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an autosomal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume83
Issue number4
DOIs
StatePublished - Apr 1977

ASJC Scopus subject areas

  • Ophthalmology

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