A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock

Ian D. Klepper, Richard F. Kucera, Neal B. Kindig, Duane L. Sherrill, Giles F. Filley

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"Carbicarb" (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO3 and NasCO3, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO3 in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO2 output), along with arterial and mixed venous PCO2, increased significantly less with CBC than with NaHCO3 for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO3 for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalJournal of Critical Care
Issue number4
StatePublished - Dec 1988


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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