A Comparison of Pharmaceutical Product Performance of Albuterol Inhalers Available in the United States and Those Obtained in a Mexican Border Town

Meira Nocella, Emily Kilber, Brittney Witmer, Kelly Karlage, Paul B Myrdal

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: American residents travel to Mexico to purchase medications for a fraction of US cost and frequently without prescription requirements. A previous bioequivalence study found differences in lung function measures between 2 brands of Mexican-manufactured albuterol inhalers (both 100 μg/puff). An investigation of the pharmaceutical performance of different inhalers available may illuminate why different clinical results may be observed and offer insight to consumer and provider expectations of such products. Objective: The purpose of this study is to provide some reasonable expectations for a medical tourist who shops in Mexico for albuterol metered dose inhalers (MDIs) or for their health care providers by comparing pharmaceutical product performance of the consumer-available brands. Methods: Five different albuterol MDI products were purchased in Nogales, Mexico. The albuterol content was quantified through high-performance liquid chromatography. The inhalers were analyzed to determine the amount of the albuterol dose that can be considered respirable and compared with the findings from 2 US innovator products. Results: The mean respirable mass for each brand of albuterol MDI was compared with that of the other 4 brands and the 2 US innovator products using Student's t test. All evaluations showed significant differences (P

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalJournal of Pharmacy Technology
Volume31
Issue number6
DOIs
StatePublished - Dec 1 2015

Keywords

  • asthma
  • inhalers
  • international medicine/issues
  • medication safety
  • pharmaceutics
  • β-2-adrenergic agonists

ASJC Scopus subject areas

  • Pharmaceutical Science

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