A comparison of two methods to determine the solubility of compounds in aerosol propellants

Abhishek Gupta, Paul B. Myrdal

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A new on-line reverse phase HPLC method for determining the solubility of compounds in propellant based metered dose inhaler (MDI) formulations was compared with a conventional method. The new method employs a direct injection from a MDI vial into the needle injector port of a manual injector. To evaluate the two methods, beclomethasone dipropionate (BDP), 5,5-diphenyl hydantoin and 3,3′-diindolylmethane, were used as model compounds in propellant HFA-134a. Comparison was performed by analyzing known and unknown concentrations of BDP in various combinations of HFA-134a and ethanol. In addition, the solubility of 5,5-diphenyl hydantoin and 3,3′-diindolylmethane were determined in HFA-134a using both the new and the conventional methods. The two methods were found to be in good agreement with each other, with the new direct injection technique offering enhanced precision and accuracy along with considerable reduction in analysis time.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume292
Issue number1-2
DOIs
StatePublished - Mar 23 2005

Keywords

  • Aerosols
  • Comparison
  • Direct injection method
  • HFA-134a
  • HPLC
  • Metered dose inhalers
  • Propellant
  • Solubility

ASJC Scopus subject areas

  • Pharmaceutical Science

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