A complex rearrangement of chromosome 7 in human astrocytoma

Anjan Misra, Malgorzata Pellarin, Joan R. Shapiro, Burt G. Feuerstein

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume151
Issue number2
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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