A controlled trial of cimetidine for the treatment of nonulcer dyspepsia

P. Lance, C. Wastell, K. F.R. Schiller

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Sixty patients with nonulcer dyspepsia took cimetidine 1 g daily or a placebo for 5 weeks in a double-blind irial. Thirtyfour men and 26 women with normal double-contrast barium meals were included. Five percent had the endoscopic appearances of duodenitis. Symptoms improved during treatment in 62% of those taking cimetidine and in 54% of the placebo group (NS, p = 0.5). We suggest that significant duodenitis is uncommon in the absence of active or quiescent duodenal ulcer disease. From this study there is no evidence that cimetidine benefits those patients with normal double-contrast barium meals and no duodenitis endoscopically who nonetheless have symptoms similar to those of peptic ulcer disease.

Original languageEnglish (US)
Pages (from-to)414-418
Number of pages5
JournalJournal of clinical gastroenterology
Volume8
Issue number4
DOIs
StatePublished - Aug 1986
Externally publishedYes

Keywords

  • Cimetidine
  • Duodenitis
  • Nonulcer dyspepsia

ASJC Scopus subject areas

  • Gastroenterology

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