A direct amine-palladium acetate cocatalyzed saegusa oxidation reaction of unmodified aldehydes to α,β-unsaturated aldehydes

Jin Zhu, Jie Liu, Ruoqun Ma, Hexin Xie, Jian Li, Hualiang Jiang, Wei Wang

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

A direct preparation of synthetically useful α,β-unsaturated aldehydes from readily available aldehydes has been developed. The process is effectively cocatalyzed by an amine-palladium acetate to give rise to α,β-unsaturated aldehydes in moderate to good yields (41-62%). The reaction features the use of unmodified aldehydes rather than enol silyl ethers, which are used in a typical Saegusa oxidation reaction.

Original languageEnglish (US)
Pages (from-to)1229-1232
Number of pages4
JournalAdvanced Synthesis and Catalysis
Volume351
Issue number9
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Aminocatalysis
  • Organocatalysis
  • Saegusa reaction
  • α,β-unsaturated aldehydes

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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