A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes

Richard J. Caselli, Eric M. Reiman, Joseph G. Hentz, Dbavid Osborne, Gene E. Alexander, Bradley F. Boeve

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Study Objectives: To correlate memory measures with a trait measure of chronic daytime somnolence in cognitively normal individuals with different gene doses of the apolipoprotein E (APOE) e4 allele, a common Alzheimer's disease susceptibility gene. Design: Cross-sectional, exploratory study of cognitive abilities in APOE e4 homozygotes (HMZ) (n=42), heterozygotes (HTZ), (n=42) and noncarriers (NC) (n=42) who are matched for age, gender, educational level, and family history of dementia. Setting: Tertiary care academic medical center Participants: Cognitively normal residents of Maricopa County, Arizona who are 30-70 years of age, genotyped for APOE, and have no history of a sleep disorder Interventions: N/A Measurements: Epworth Sleepiness Scale (ESS) and a battery of neuropsychological tests Results: Age, education, gender, and insomnia complaints did not significantly differ among groups. Despite normal baseline memory scores, memory declined with increasing ESS on all eight memory measures in the HMZ, two of eight in the HTZ, and one of eight in the NC. Differences between HMZ and NC on the slope of memory decline with increasing ESS reached statistical significance on two verbal memory measures, AVLT Long-Term Memory (p=0.048) and Percent Delayed Recall (p=0.035). Conclusions: Chronic daytime somnolence is associated with a distinctive decline in verbal memory in cognitively normal APOE e4 HMZ, a group at particularly high risk of Alzheimer's disease. Additional studies are needed to confirm these exploratory findings and to determine the effects of acute somnolence on cognition in these genetic subgroups.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalSleep
Volume25
Issue number4
StatePublished - Jun 15 2002

Fingerprint

Apolipoprotein E4
Homozygote
Apolipoproteins E
Heterozygote
Alzheimer Disease
Aptitude
Long-Term Memory
Neuropsychological Tests
Disease Susceptibility
Sleep Initiation and Maintenance Disorders
Tertiary Healthcare
Cognition
Genes
Dementia
Cross-Sectional Studies
Alleles
Education

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Memory
  • Somnolence

ASJC Scopus subject areas

  • Physiology

Cite this

Caselli, R. J., Reiman, E. M., Hentz, J. G., Osborne, D., Alexander, G. E., & Boeve, B. F. (2002). A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. Sleep, 25(4), 447-453.

A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. / Caselli, Richard J.; Reiman, Eric M.; Hentz, Joseph G.; Osborne, Dbavid; Alexander, Gene E.; Boeve, Bradley F.

In: Sleep, Vol. 25, No. 4, 15.06.2002, p. 447-453.

Research output: Contribution to journalArticle

Caselli, RJ, Reiman, EM, Hentz, JG, Osborne, D, Alexander, GE & Boeve, BF 2002, 'A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes', Sleep, vol. 25, no. 4, pp. 447-453.
Caselli RJ, Reiman EM, Hentz JG, Osborne D, Alexander GE, Boeve BF. A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. Sleep. 2002 Jun 15;25(4):447-453.
Caselli, Richard J. ; Reiman, Eric M. ; Hentz, Joseph G. ; Osborne, Dbavid ; Alexander, Gene E. ; Boeve, Bradley F. / A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. In: Sleep. 2002 ; Vol. 25, No. 4. pp. 447-453.
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N2 - Study Objectives: To correlate memory measures with a trait measure of chronic daytime somnolence in cognitively normal individuals with different gene doses of the apolipoprotein E (APOE) e4 allele, a common Alzheimer's disease susceptibility gene. Design: Cross-sectional, exploratory study of cognitive abilities in APOE e4 homozygotes (HMZ) (n=42), heterozygotes (HTZ), (n=42) and noncarriers (NC) (n=42) who are matched for age, gender, educational level, and family history of dementia. Setting: Tertiary care academic medical center Participants: Cognitively normal residents of Maricopa County, Arizona who are 30-70 years of age, genotyped for APOE, and have no history of a sleep disorder Interventions: N/A Measurements: Epworth Sleepiness Scale (ESS) and a battery of neuropsychological tests Results: Age, education, gender, and insomnia complaints did not significantly differ among groups. Despite normal baseline memory scores, memory declined with increasing ESS on all eight memory measures in the HMZ, two of eight in the HTZ, and one of eight in the NC. Differences between HMZ and NC on the slope of memory decline with increasing ESS reached statistical significance on two verbal memory measures, AVLT Long-Term Memory (p=0.048) and Percent Delayed Recall (p=0.035). Conclusions: Chronic daytime somnolence is associated with a distinctive decline in verbal memory in cognitively normal APOE e4 HMZ, a group at particularly high risk of Alzheimer's disease. Additional studies are needed to confirm these exploratory findings and to determine the effects of acute somnolence on cognition in these genetic subgroups.

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