A DNA Polymerase α-Associated 56 kDa Protein Kinase

Vickie M. Peck, Eugene W. Gerner, Anne E. Cress

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume190
Issue number2
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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