Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - 1993|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology