A DNA Polymerase α-Associated 56 kDa Protein Kinase

V. M. Peck, E. W. Gerner, Anne E Cress

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume190
Issue number2
DOIs
StatePublished - Jan 29 1993

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DNA-Directed DNA Polymerase
Protein Kinases
Phosphotransferases
Polynucleotide 5'-Hydroxyl-Kinase
Immunologic Techniques
Peptides
DNA Replication
Histones
Drosophila
Cell Cycle
Embryonic Structures
Cells
DNA
Experiments

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

A DNA Polymerase α-Associated 56 kDa Protein Kinase. / Peck, V. M.; Gerner, E. W.; Cress, Anne E.

In: Biochemical and Biophysical Research Communications, Vol. 190, No. 2, 29.01.1993, p. 325-331.

Research output: Contribution to journalArticle

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