A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock

Toshinobu Kazui, Phat L. Tran, Tia R. Pilikian, Katie M. Marsh, Raymond Runyan, John Konhilas, Richard Smith, Zain I. Khalpey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. Case presentation: This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. A minimally-invasive off-pump LVAD was established by draining from the left ventricle and returning to the right axillary artery with distal arterial banding to prevent right upper extremity hyperperfusion. Amniotic stem cells were injected intramyocardially at the left ventricular apex, lateral wall, inferior wall, and right subclavian vein. Conclusion: The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.

Original languageEnglish (US)
Article number80
JournalJournal of Cardiothoracic Surgery
Volume12
Issue number1
DOIs
StatePublished - Sep 7 2017

Keywords

  • Amniotic stem cell
  • Extracorporeal device
  • Left Ventricular Assist Device (LVAD)
  • Off-pump
  • Refractory Cardiogenic Shock (RCS)

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock'. Together they form a unique fingerprint.

  • Cite this