A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock

Toshinobu Kazui, Phat L. Tran, Tia R. Pilikian, Katie M. Marsh, Raymond Runyan, John Konhilas, Richard Smith, Zain I. Khalpey

Research output: Research - peer-reviewArticle

Abstract

Background: Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. Case presentation: This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. A minimally-invasive off-pump LVAD was established by draining from the left ventricle and returning to the right axillary artery with distal arterial banding to prevent right upper extremity hyperperfusion. Amniotic stem cells were injected intramyocardially at the left ventricular apex, lateral wall, inferior wall, and right subclavian vein. Conclusion: The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.

LanguageEnglish (US)
Article number80
JournalJournal of Cardiothoracic Surgery
Volume12
Issue number1
DOIs
StatePublished - Sep 7 2017

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Cardiogenic Shock
Stem Cells
Equipment and Supplies
Therapeutics
Sternotomy
Cell- and Tissue-Based Therapy
Axillary Artery
Subclavian Vein
Myocardial Reperfusion
Cardiopulmonary Bypass
Upper Extremity
Heart Ventricles
Regeneration
Injections

Keywords

  • Amniotic stem cell
  • Extracorporeal device
  • Left Ventricular Assist Device (LVAD)
  • Off-pump
  • Refractory Cardiogenic Shock (RCS)

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock. / Kazui, Toshinobu; Tran, Phat L.; Pilikian, Tia R.; Marsh, Katie M.; Runyan, Raymond; Konhilas, John; Smith, Richard; Khalpey, Zain I.

In: Journal of Cardiothoracic Surgery, Vol. 12, No. 1, 80, 07.09.2017.

Research output: Research - peer-reviewArticle

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AU - Marsh,Katie M.

AU - Runyan,Raymond

AU - Konhilas,John

AU - Smith,Richard

AU - Khalpey,Zain I.

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AB - Background: Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. Case presentation: This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. A minimally-invasive off-pump LVAD was established by draining from the left ventricle and returning to the right axillary artery with distal arterial banding to prevent right upper extremity hyperperfusion. Amniotic stem cells were injected intramyocardially at the left ventricular apex, lateral wall, inferior wall, and right subclavian vein. Conclusion: The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.

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KW - Off-pump

KW - Refractory Cardiogenic Shock (RCS)

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