Abstract
An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.
Original language | English (US) |
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Pages (from-to) | 7327-7330 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 41 |
DOIs | |
State | Published - Oct 9 2006 |
Externally published | Yes |
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Keywords
- DOTA
- Molecular imaging
- MRI
- T relaxivity
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. / Yoo, Byunghee; Pagel, Mark "Marty".
In: Tetrahedron Letters, Vol. 47, No. 41, 09.10.2006, p. 7327-7330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe
AU - Yoo, Byunghee
AU - Pagel, Mark "Marty"
PY - 2006/10/9
Y1 - 2006/10/9
N2 - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.
AB - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.
KW - DOTA
KW - Molecular imaging
KW - MRI
KW - T relaxivity
UR - http://www.scopus.com/inward/record.url?scp=33748290325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748290325&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2006.08.019
DO - 10.1016/j.tetlet.2006.08.019
M3 - Article
AN - SCOPUS:33748290325
VL - 47
SP - 7327
EP - 7330
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 41
ER -