A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo, Mark "Marty" Pagel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

Original languageEnglish (US)
Pages (from-to)7327-7330
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number41
DOIs
StatePublished - Oct 9 2006
Externally publishedYes

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Molecular imaging
Molecular Probes
Molecular Imaging
Acetic Acid
Glycine
Ligands
Peptides
cyclen

Keywords

  • DOTA
  • Molecular imaging
  • MRI
  • T relaxivity

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. / Yoo, Byunghee; Pagel, Mark "Marty".

In: Tetrahedron Letters, Vol. 47, No. 41, 09.10.2006, p. 7327-7330.

Research output: Contribution to journalArticle

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