A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo; Mark D. Pagel

doi:10.1016/j.tetlet.2006.08.019

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-^tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

Original language	English (US)
Pages (from-to)	7327-7330
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2006.08.019
State	Published - Oct 9 2006

Keywords

DOTA
MRI
Molecular imaging
T relaxivity

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.",

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AU - Pagel, Mark D.

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N2 - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

AB - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

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KW - Molecular imaging

KW - T relaxivity

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