Abstract
An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7327-7330 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue number | 41 |
| DOIs | |
| State | Published - Oct 9 2006 |
Keywords
- DOTA
- MRI
- Molecular imaging
- T relaxivity
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Yoo, B., & Pagel, M. D. (2006). A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Letters, 47(41), 7327-7330. https://doi.org/10.1016/j.tetlet.2006.08.019