A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo, Mark D. Pagel

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

Original languageEnglish (US)
Pages (from-to)7327-7330
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number41
DOIs
StatePublished - Oct 9 2006

Keywords

  • DOTA
  • MRI
  • Molecular imaging
  • T relaxivity

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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