A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo, Mark "Marty" Pagel

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

Original languageEnglish (US)
Pages (from-to)7327-7330
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number41
DOIs
StatePublished - Oct 9 2006
Externally publishedYes

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Molecular imaging
Molecular Probes
Molecular Imaging
Acetic Acid
Glycine
Ligands
Peptides
cyclen

Keywords

  • DOTA
  • Molecular imaging
  • MRI
  • T relaxivity

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. / Yoo, Byunghee; Pagel, Mark "Marty".

In: Tetrahedron Letters, Vol. 47, No. 41, 09.10.2006, p. 7327-7330.

Research output: Contribution to journal › Article

Yoo, B & Pagel, MM 2006, 'A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe', Tetrahedron Letters, vol. 47, no. 41, pp. 7327-7330. https://doi.org/10.1016/j.tetlet.2006.08.019
Yoo B, Pagel MM. A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Letters. 2006 Oct 9;47(41):7327-7330. https://doi.org/10.1016/j.tetlet.2006.08.019
Yoo, Byunghee ; Pagel, Mark "Marty". / A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 41. pp. 7327-7330.
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