A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo; Mark D. Pagel

doi:10.1016/j.tetlet.2006.08.019

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Byunghee Yoo, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-^tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

Original language	English (US)
Pages (from-to)	7327-7330
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2006.08.019
State	Published - Oct 9 2006

Keywords

DOTA
MRI
Molecular imaging
T relaxivity

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe",

abstract = "An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.",

keywords = "DOTA, MRI, Molecular imaging, T relaxivity",

author = "Byunghee Yoo and Pagel, {Mark D.}",

note = "Funding Information: This work was supported by the US Army Medical Research and Material Command under #W81XWH-04-1-0731. ",

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T1 - A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

AU - Yoo, Byunghee

AU - Pagel, Mark D.

N1 - Funding Information: This work was supported by the US Army Medical Research and Material Command under #W81XWH-04-1-0731.

PY - 2006/10/9

Y1 - 2006/10/9

N2 - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

AB - An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization.

KW - DOTA

KW - MRI

KW - Molecular imaging

KW - T relaxivity

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DO - 10.1016/j.tetlet.2006.08.019

M3 - Article

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SP - 7327

EP - 7330

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 41

ER -

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

Abstract

Keywords

ASJC Scopus subject areas

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