A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions

Jon K.F. Geirsson, Jon T. Njardarson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This paper describes a concise and effective synthesis of methyl α-phosphonoaryl acetates, effected by reacting α-phosphono carbanions with methyl chloroformate. Yields are high, and the purification of the products is readily achieved with column chromatography.

Original languageEnglish (US)
Pages (from-to)9071-9072
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number48
DOIs
StatePublished - Nov 28 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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