A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions

Jon K F Geirsson, Jon T Njardarson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This paper describes a concise and effective synthesis of methyl α-phosphonoaryl acetates, effected by reacting α-phosphono carbanions with methyl chloroformate. Yields are high, and the purification of the products is readily achieved with column chromatography.

Original languageEnglish (US)
Pages (from-to)9071-9072
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number48
DOIs
StatePublished - Nov 28 1994
Externally publishedYes

Fingerprint

Column chromatography
Purification
Chromatography
Esters
methyl chloroformate
methyl acetate

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions. / Geirsson, Jon K F; Njardarson, Jon T.

In: Tetrahedron Letters, Vol. 35, No. 48, 28.11.1994, p. 9071-9072.

Research output: Contribution to journalArticle

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