A fast model of a multiple-pinhole SPECT imaging system

Kevin Gross, Matthew A Kupinski, Jacob Y. Hesterman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The Center for Gamma-Ray Imaging is developing a number of small-animal SPECT imaging systems. These systems consist of multiple stationary detectors, each of which has its own multiple-pinhole collimator. The location of the pinhole plates (i.e., magnification), the number of pinholes within each plate, as well the pinhole locations are all adjustable. The performance of the Bayesian ideal observer sets the upper limit on task performance and can be used to optimize imaging hardware, such as pinhole configurations. Markov-chain Monte Carlo techniques have been developed to compute the ideal observer but require complete knowledge of the statistics of both the imaging system (such as the noise) and the class of random objects being imaged, in addition to an accurate forward model connecting the object to the image. Ideal observer computations using Monte Carlo techniques are burdensome because the forward model must be simulated millions of times for each imaging system. We present an efficient technique for computing the Bayesian ideal observer for multiple-pinhole, small-animal SPECT systems that accounts for both the finite-size of the pinholes and the stochastic nature of the objects being imaged. This technique relies on an efficient, radiometrically correct forward model that maps an object to an image in less than 20 milliseconds. An analysis of the error of the forward model, as well as the results of a ROC study using the ideal observer test statistic is presented.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsM.P. Eckstein, Y. Jiang
Pages118-127
Number of pages10
Volume5749
DOIs
StatePublished - 2005
EventMedical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment - San Diego, CA, United States
Duration: Feb 15 2005Feb 17 2005

Other

OtherMedical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment
CountryUnited States
CitySan Diego, CA
Period2/15/052/17/05

Fingerprint

SPECT
pinholes
Imaging System
Imaging systems
Observer
Monte Carlo Techniques
Animals
Statistics
Imaging techniques
Imaging
animals
Gamma rays
Model
Markov processes
Gamma Rays
statistics
Markov Chain Monte Carlo
Test Statistic
Detectors
Hardware

Keywords

  • Hardware Optimization
  • Ideal Observer
  • Lumpy Object
  • Markov-Chain Monte Carlo
  • SPECT

ASJC Scopus subject areas

  • Engineering(all)
  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Gross, K., Kupinski, M. A., & Hesterman, J. Y. (2005). A fast model of a multiple-pinhole SPECT imaging system. In M. P. Eckstein, & Y. Jiang (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5749, pp. 118-127). [15] https://doi.org/10.1117/12.595605

A fast model of a multiple-pinhole SPECT imaging system. / Gross, Kevin; Kupinski, Matthew A; Hesterman, Jacob Y.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / M.P. Eckstein; Y. Jiang. Vol. 5749 2005. p. 118-127 15.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gross, K, Kupinski, MA & Hesterman, JY 2005, A fast model of a multiple-pinhole SPECT imaging system. in MP Eckstein & Y Jiang (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5749, 15, pp. 118-127, Medical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment, San Diego, CA, United States, 2/15/05. https://doi.org/10.1117/12.595605
Gross K, Kupinski MA, Hesterman JY. A fast model of a multiple-pinhole SPECT imaging system. In Eckstein MP, Jiang Y, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5749. 2005. p. 118-127. 15 https://doi.org/10.1117/12.595605
Gross, Kevin ; Kupinski, Matthew A ; Hesterman, Jacob Y. / A fast model of a multiple-pinhole SPECT imaging system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / M.P. Eckstein ; Y. Jiang. Vol. 5749 2005. pp. 118-127
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