A first-generation haplotype map of maize

Michael A. Gore, Jer Ming Chia, Robert J. Elshire, Qi Sun, Elhan S. Ersoz, Bonnie L. Hurwitz, Jason A. Peiffer, Michael D. McMullen, George S. Grills, Jeffrey Ross-Ibarra, Doreen H. Ware, Edward S. Buckler

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515 Scopus citations

Abstract

Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.

Original languageEnglish (US)
Pages (from-to)1115-1117
Number of pages3
JournalScience
Volume326
Issue number5956
DOIs
StatePublished - Nov 20 2009

ASJC Scopus subject areas

  • General

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    Gore, M. A., Chia, J. M., Elshire, R. J., Sun, Q., Ersoz, E. S., Hurwitz, B. L., Peiffer, J. A., McMullen, M. D., Grills, G. S., Ross-Ibarra, J., Ware, D. H., & Buckler, E. S. (2009). A first-generation haplotype map of maize. Science, 326(5956), 1115-1117. https://doi.org/10.1126/science.1177837