A fresh look at an ancient receptor family: Emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation

Shenfeng Qiu, Kimberly M. Korwek, Edwin J. Weeber

Research output: Contribution to journalShort survey

53 Scopus citations

Abstract

The well-known family of low-density lipoprotein receptors represents a collection of ancient membrane receptors that have been remarkably conserved throughout evolution. These multifunctional receptors, known to regulate cholesterol transport, are becoming increasingly interesting to the neuroscience community due to their ability to transduce a diversity of extracellular signals across the membrane in the adult CNS. Their roles in modulating synaptic plasticity and necessity in hippocampus-specific learning and memory have recently come to light. In addition, genetic, biochemical and behavioral studies have implicated these signaling systems in a number of human neurodegenerative and neuropsychiatric disorders involving loss of cognitive ability, such as Alzheimer's disease, schizophrenia and autism. This review describes the known functions of these receptors and discusses their potential role in processes of synaptic regulation and memory formation.

Original languageEnglish (US)
Pages (from-to)16-29
Number of pages14
JournalNeurobiology of Learning and Memory
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Low density lipoprotein receptors
  • Reelin
  • Synaptic plasticity
  • apoE

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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