A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle

T. R. Serio, N. Cahill, M. E. Prout, G. Miller

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.

Original languageEnglish (US)
Pages (from-to)8338-8343
Number of pages6
JournalJournal of virology
Volume72
Issue number10
StatePublished - Sep 23 1998

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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