A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle

Tricia R Serio, N. Cahill, M. E. Prout, G. Miller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.

Original languageEnglish (US)
Pages (from-to)8338-8343
Number of pages6
JournalJournal of Virology
Volume72
Issue number10
StatePublished - 1998
Externally publishedYes

Fingerprint

TATA box
Human herpesvirus 4
TATA Box
Life Cycle Stages
Human Herpesvirus 4
life cycle (organisms)
promoter regions
3' Flanking Region
Gene Expression
Epstein-Barr Virus Infections
DNA Replication
gene expression
DNA replication
Genes
infection
genes

ASJC Scopus subject areas

  • Immunology

Cite this

A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle. / Serio, Tricia R; Cahill, N.; Prout, M. E.; Miller, G.

In: Journal of Virology, Vol. 72, No. 10, 1998, p. 8338-8343.

Research output: Contribution to journalArticle

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